Results 81 to 90 of about 1,391,068 (260)

From 3D to 2D and back again

open access: yesNanophotonics, 2023
The prospect of massive parallelism of optics enabling fast and low energy cost operations is attracting interest for novel photonic circuits where 3-dimensional (3D) implementations have a high potential for scalability.
Dinc Niyazi Ulas   +6 more
doaj   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

open access: yesFEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu   +5 more
wiley   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

open access: yesFEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies   +3 more
wiley   +1 more source

Inverse‐Designed Dispersive Time‐Varying Nanostructures

open access: yesAdvanced Optical Materials
AbstractTime‐varying nanostructures allow to control the spatial and temporal properties of light. The temporal modulation of the nanostructures constitutes an additional degree of freedom to control their scattering properties on demand and in a reconfigurable manner.
Puneet Garg   +7 more
openaire   +5 more sources

Application of direct inverse analogy method (DIVA) and viscous design optimization techniques [PDF]

open access: yes
A direct-inverse approach to the transonic design problem was presented in its initial state at the First International Conference on Inverse Design Concepts and Optimization in Engineering Sciences (ICIDES-1).
Forbrich, D., Greff, E., Schwarten, H.
core   +1 more source

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

open access: yesFEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen   +6 more
wiley   +1 more source

TURBOMACHINERY COMPONENT DESIGN BY MEANS OF CFD

open access: yesTASK Quarterly, 2002
A short overview of the main techniques for turbomachinery blade design based on CFD is followed by a more detailed description on an Optimisation- and Inverse Design method, developed at the von Karman Institute.
RENE A. VAN DEN BRAEMBUSSCHE
doaj  

Inverse design technique for cascades [PDF]

open access: yes
A numerical technique to generate cascades is presented. The basic prescribed parameters are: inlet angle, exit pressure, and distribution of blade thickness and lift along a blade. Other sets of parameters are also discussed.
Pandolfi, M., Zannetti, L.
core   +1 more source

Prognostic Impact of European LeukemiaNet Genetic Risk Stratification System in Adult Patients With Acute Myeloid Leukemia

open access: yesAging and Cancer, EarlyView.
This study aimed to evaluate the prognostic value of ELN2017 in predicting survival outcomes and to assess the impact of clinical and molecular factors such as age, FLT3 and NPM1 mutations, and allogeneic hematopoietic stem cell transplantation (allo‐HSCT).
Mobina Shrestha   +4 more
wiley   +1 more source

Accelerated Progression of Gait Impairment in Parkinson's Disease and REM Sleep Without Atonia

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective People with Parkinson's disease (PD) and rapid eye movement (REM) sleep without atonia (RSWA) often have more severe gait disturbances compared to PD without RSWA. The association between the presence and expression of RSWA and the rate of progression of gait impairment in PD is unknown.
Sommer L. Amundsen‐Huffmaster   +11 more
wiley   +1 more source

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