Results 41 to 50 of about 55,893 (253)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Local analytic integrability for a class of degenerate planar vector fields

Advanced Nonlinear Studies
Using the normal form theory and the existence of an algebraic inverse integrating factor we characterize the local analytic integrability of the systems whose quasi-homogeneous leading term is a1y3+a2x3y,b1x5+b2x2y2 $\left({a}_{1}{y}^{3}+{a}_{2}{x}^{3}y,
Algaba Antonio, Reyes Manuel, Giné Jaume   +2 more
doaj   +1 more source

Advancements in diabetic foot insoles: a comprehensive review of design, manufacturing, and performance evaluation

Frontiers in Bioengineering and Biotechnology
The escalating prevalence of diabetes has accentuated the significance of addressing the associated diabetic foot problem as a major public health concern. Effectively offloading plantar pressure stands out as a crucial factor in preventing diabetic foot
Yuanfei Ren, Hao Wang, Xiaoshuang Song, Yanli Wu, Yongtao Lyu, Yongtao Lyu, Wei Zeng   +6 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Analysis of Factors Affecting Optical Performance of GaN-Based Micro-LEDs with Quantum Dots Films

Crystals, 2020
Optical performance in terms of light efficiency, color crosstalk and ambient contrast ratio were analyzed for blue GaN-based micro-light emitting diodes (micro-LEDs) combined with red/green quantum dots (QDs)-polymethyl methacrylate (PMMA) films.
Zhili Zhao, Xinzhong Wang, Kaidong Yang, Fang Fan, Dan Wu, Sheng Liu, Kai Wang   +6 more
doaj   +1 more source

The nondegenerate center problem and the inverse integrating factor

Bulletin des Sciences Mathématiques, 2006
This paper deals with the center-focus problem for analytic planar differential systems and, in particular, polynomial differential systems. That is, given a planar analytic differential system defined in a neighborhood of the origin of the form \[ \dot{x} = -y + p(x,y), \quad \dot{y} = x + q(x,y), \tag{1} \] where \(p(x,y)\) and \(q(x,y)\) are of ...
openaire   +1 more source

Nilpotent Systems Admitting an Algebraic Inverse Integrating Factor over $${{\mathbb{C}}((x,y))}$$ [PDF]

Qualitative Theory of Dynamical Systems, 2011
The authors study the existence of an inverse integrating factors \(V\) for certain planar vector fields. The main reason to study its existence is that, using an inverse integrating factor, it is possible to compute a first integral of the vector field.
Algaba, Antonio, García, Cristóbal, Reyes, Manuel   +2 more
openaire   +2 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Neural proximity, vascular remodeling, and perineural immune exclusion across the cervical neoplasia spectrum – a whole-slide, nerve-anchored spatial analysis of 135 cases

Polish Journal of Pathology
Cervical carcinogenesis unfolds within a complex tissue ecosystem. While epithelial biomarkers and HPV status inform risk, the contribution of local neural circuits and their relationship to angiogenesis and cytotoxic immunity remains insufficiently ...
Giorgi-Jemal Gogitidze, Shota Kepuladze, George Burkadze   +2 more
doaj   +1 more source