Results 61 to 70 of about 55,893 (253)

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

open access: yesMolecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant   +7 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

open access: yesFEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin   +12 more
wiley   +1 more source

Long‐Term Monitoring of ApoE4 within Aqueous Humor Using Intraocular Lenses Containing Target‐Responsive Inverse Opal Hydrogel

open access: yesSmall Structures
Neurodegenerative diseases, including Alzheimer's disease (AD), pose significant challenges to global healthcare because of their irreversible postsymptomatic progression. Conventional radiographic techniques have limitations in early detection, owing to
Hyo Lee   +8 more
doaj   +1 more source

Impact of Combustible Linings in the Simulated Fluid Dynamics of a Compartment Fire

open access: yesFire
The increasing use of engineered timber in modern architecture raises critical concerns about fire safety, particularly when combustible linings are exposed within compartments.
Ignacio Calderón   +2 more
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

open access: yesFEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks   +4 more
wiley   +1 more source

Water‐Immersed GaP Huygens’ Meta‐Optics for Visible Structured Light Generation

open access: yesAdvanced Science
Underwater photonics is essential for imaging and analysis in biomedical technologies, as well as for communication and autonomous vehicle networks in the Internet of Underwater Things (IoUT).
Jia‐Hua Lee   +8 more
doaj   +1 more source

Comprehensive analysis of cellular heterogeneity in the tumor microenvironment reveals TUBG1 as an immunosuppressive regulator in hepatocellular carcinoma

open access: yesHeliyon
Heterogeneity of the tumor microenvironment (TME) within and among patients with liver cancer has significant effects on their responses to therapies. Systematic and detailed characterization of the TME can guide precision therapy.
Yacan Zhao, Yibo Huang
doaj   +1 more source

Research on SAR data integrated processing methodology oriented on earth environment factor inversions

open access: yesInternational Journal of Digital Earth, 2017
As an important advanced technique in the field of Earth observations, Synthetic Aperture Radar (SAR) plays a key role in the study of global environmental change, resources exploration, disaster mitigation, urban environments, and even lunar exploration.
Huadong Guo   +18 more
openaire   +2 more sources

Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley   +1 more source

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