Results 41 to 50 of about 1,566,449 (300)
Fuzzy logic as a financial evaluation tool for investment projects
Ecuador is a country with a wide variety of food products with high nutritional and sensory value that according to data from state agencies has a growing population orientation towards health care, well-being, ecological care and active lifestyles ...
Kleber Patricio Vidal Beltrán +2 more
doaj +1 more source
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Este artículo propone un análisis comparativo del fenómeno de la extrahección en Colombia y la República Democrática del Congo, explorando cómo la extracción violenta de minerales estratégicos se articula con estructuras estatales cooptadas, actores ...
Laura Elízabeth Martínez Galindo +1 more
doaj +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Los flujos de inversión entre España y Japón [PDF]
En este artículo se presentan los rasgos básicos de la inversión directa japonesa desde y hacia el exterior, con un detallado análisis de los flujos de inversión entre Japón y España.
Pérez López, Carmen
core
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Mineral composition modulates plant health, agro-morphological attributes, and functional quality in coffee, yet large-scale evaluations remain limited. In 150 Coffea arabica L. accessions, we quantified grain minerals (Ca, K, Mg, Na, P, Zn, Cu, Fe, Mn);
Ester Choque-Incaluque +9 more
doaj +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
La independencia de las agencias de competencia es vital para garantizar que estas operen de forma objetiva y técnica. Múltiples trabajos se han escrito respecto de la importancia de establecer un marco institucional sólido que proteja a estas entidades ...
Jeysson Sandoval Valer +2 more
doaj
ACTITUDES HACIA LA INVERSIÓN SOCIALMENTE RESPONSABLE
La transición hacia una economÃa verde y circular requiere necesariamente una transformación del sector financiero y, en concreto, un desarrollo de la denominada Inversión Socialmente Responsable. Esta investigación tiene por objetivo identificar el nivel de conocimiento y las creencias sobre este tipo de inversión, asà como estimar la ...
openaire +1 more source

