Results 21 to 30 of about 410,766 (246)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Efectos socioambientales de la explotación gasífera y petrolífera en la cuenca neuquina
Cuadernos de Antropología Social, 2000 En este trabajo analizamos los efectos socioeconómicos acaecidos como consecuencia de la explotación de hidrocarburos en la llamada cuenca neuquina en general y en la provincia de Neuquén en particular.
Alejandro Balazote Oliver
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Transferencia de riesgos en la cadena de valor de la manzana de exportación
UCMaule, 2015 Esta investigación describe, en el contexto de la globalización alimentaria, la transferencia de riesgos producida desde el escenario global al local, a partir de la interacción económica entre un packing exportador y una empresa productora de manzanas ...
Leonardo Alfredo Soto Troncoso
doaj
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Contabilidad y Negocios: Revista del Departamento Académico de Ciencias Administrativas, 2014 This paper proposes a new methodology for selecting a pension fund base on the probability of loss for its customers. The methodology includes the historical performance of the portfolio between, March 2006 and May 2013, and projects its profitability ...
Juan Carlos Ames Santillán
doaj
QuipukamayocObjetivo: Determinar la incidencia de la evolución intertemporal de la situación financiera de un proyecto de inversión en la estimación de su rentabilidad. Métodos: Se realizó un estudio cuantitativo de alcance explicativo.
Juan Carlos Ames Santillán
doaj +1 more source
La inversión en energías renovables en Argentina
Revista de Economía Institucional, 2017 En este artículo se analiza en qué medida los factores del entorno de la política energética de un país en desarrollo, tal como Argentina, determinan la evolución de la inversión en energías renovables.
Marina Recalde
doaj +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Fuzzy logic as a financial evaluation tool for investment projects
Revista Arbitrada Interdisciplinaria Koinonía, 2019 Ecuador is a country with a wide variety of food products with high nutritional and sensory value that according to data from state agencies has a growing population orientation towards health care, well-being, ecological care and active lifestyles ...
Kleber Patricio Vidal Beltrán +2 more
doaj +1 more source