Results 31 to 40 of about 1,566,449 (300)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Efectos socioambientales de la explotación gasífera y petrolífera en la cuenca neuquina

Cuadernos de Antropología Social, 2000
En este trabajo analizamos los efectos socioeconómicos acaecidos como consecuencia de la explotación de hidrocarburos en la llamada cuenca neuquina en general y en la provincia de Neuquén en particular.
Alejandro Balazote Oliver
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Higher-order topological insulators and superconductors protected by inversion symmetry [PDF]

, 2018
Here, higher-order topological insulators and superconductors protected by inversion symmetry are investigated. These phases are characterized by gapped bulk and surface with gapless modes confined to hinges or corners of the sample.
E. Khalaf
semanticscholar   +1 more source

Training‐Image Based Geostatistical Inversion Using a Spatial Generative Adversarial Neural Network [PDF]

arXiv.org, 2017
Probabilistic inversion within a multiple‐point statistics framework is often computationally prohibitive for high‐dimensional problems. To partly address this, we introduce and evaluate a new training‐image based inversion approach for complex geologic ...
E. Laloy, R. Hérault, D. Jacques, N. Linde   +3 more
semanticscholar   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

La inversión en energías renovables en Argentina

Revista de Economía Institucional, 2017
En este artículo se analiza en qué medida los factores del entorno de la política energética de un país en desarrollo, tal como Argentina, determinan la evolución de la inversión en energías renovables.
Marina Recalde
doaj   +1 more source

Sarbanes-Oxley\u27s Insight: The Role of Distrust [PDF]

, 2008
El presente trabajo tiene por objetivo analizar la regulación aplicable a la inversión extranjera en la Argentina en el período 1853-2007. Su alcance no se limitará a normas de nivel internacional o nacional, por el contrario una de las razones que ...
Perrone, Nicolás Marcelo, Tussie, Diana
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Historical pension funds performance and application of a selection criteria based on the probability of loss

Contabilidad y Negocios: Revista del Departamento Académico de Ciencias Administrativas, 2014
This paper proposes a new methodology for selecting a pension fund base on the probability of loss for its customers. The methodology includes the historical performance of the portfolio between, March 2006 and May 2013, and projects its profitability ...
Juan Carlos Ames Santillán
doaj