Results 71 to 80 of about 1,253,126 (321)
Inversion of DNA charge by a positive polymer via fractionalization of the polymer charge
, 2002 Charge inversion of a DNA double helix by an oppositely charged flexible polyelectrolyte (PE) is widely used for gene delivery. It is considered here in terms of discrete charges of DNA. We concentrate on the worst scenario case when in the neutral state
B.I. Shklovskii +23 more
core +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Geophysical Research Letters, 2023 Recent estimates of the crustal thickness of Mars show a bimodal result of either ∼20 or ∼40 km beneath the InSight lander. We propose an approach based on random matrix theory applied to receiver functions (RFs) to further constrain the subsurface ...
Rakshit Joshi +6 more
doaj +1 more source
Inverse Sets and Inverse Correspondences over Inverse Semigroups
Semigroup Forum38 ...
openaire +2 more sources
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Regional Responses of Vegetation Productivity to the Two Phases of ENSO
Geophysical Research LettersThe two phases of El‐Niño‐Southern Oscillation (ENSO) influence both regional and global terrestrial vegetation productivity on inter‐annual scales.
Mousong Wu +9 more
doaj +1 more source
Efficient unified Montgomery inversion with multibit shifting [PDF]
, 2004 Computation of multiplicative inverses in finite fields GF(p) and GF(2/sup n/) is the most time-consuming operation in elliptic curve cryptography, especially when affine co-ordinates are used.
Gutub, Adnan Abdül-Aziz +3 more
core
A Generalization of Abel Inversion to non axisymmetric density distribution
, 2001 Abel Inversion is currently used in laser-plasma studies in order to estimate the electronic density $n_e$ from the phase-shift map $\delta \phi$ obtained via interferometry.
A. Giulietti +5 more
core +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source