Results 61 to 70 of about 278,951 (267)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Joint Inversion of Receiver Functions and Apparent Incidence Angles to Determine the Crustal Structure of Mars

Geophysical Research Letters, 2023
Recent estimates of the crustal thickness of Mars show a bimodal result of either ∼20 or ∼40 km beneath the InSight lander. We propose an approach based on random matrix theory applied to receiver functions (RFs) to further constrain the subsurface ...
Rakshit Joshi, Brigitte Knapmeyer‐Endrun, Klaus Mosegaard, M. A. Wieczorek, Heiner Igel, Ulrich R. Christensen, Philippe Lognonné   +6 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Uterine Inversion

Obstetric Anesthesia Digest
(BJA Educ. 2024;24(4):109e112. doi:10.1016/j.bjae.2024.01.004. Epub February 2024.) Uterine inversion (UI) is a serious condition where the uterus protrudes into the endometrial cavity and in more extreme cases, through the vaginal orifice.
Kullar M, Morgan A, Carlson K.
europepmc   +3 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Lagrange inversion

Journal of Combinatorial Theory, Series A, 2016
We give a survey of the Lagrange inversion formula, including different versions and proofs, with applications to combinatorial and formal power series identities.
openaire   +3 more sources

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Regional Responses of Vegetation Productivity to the Two Phases of ENSO

Geophysical Research Letters
The two phases of El‐Niño‐Southern Oscillation (ENSO) influence both regional and global terrestrial vegetation productivity on inter‐annual scales.
Mousong Wu, Fei Jiang, Marko Scholze, Deliang Chen, Weimin Ju, Songhan Wang, Thomas Kaminski, Zhengyao Lu, Michael Vossbeck, Minjie Zheng   +9 more
doaj   +1 more source

Together But Different: The Subgenomes of the Bimodal Eleutherine Karyotypes Are Differentially Organized

Frontiers in Plant Science, 2019
Bimodal karyotypes are characterized by the presence of two sets of chromosomes of contrasting size. Eleutherine bulbosa (2n = 12) presents a bimodal karyotype with a large chromosome pair, which has a pericentric inversion in permanent heterozygosity ...
Mariana Báez, Magdalena Vaio, Steven Dreissig, Veit Schubert, Andreas Houben, Andrea Pedrosa-Harand   +5 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source