Results 71 to 80 of about 3,867,281 (278)
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Document Reordering for Efficient Dynamic Pruning in Traditional and Learned Sparse Retrieval
IEEE AccessLarge scale Web search engines conduct first-stage retrieval using a traditional inverted index, on which they are expected to execute billions of queries on a very tight budget, i.e., less than 200 milliseconds.
Erman Yafay, Ismail Sengor Altingovde
doaj +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso +5 more
wiley +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
On Inverted Index Compression for Search Engine Efficiency [PDF]
, 2014 Efficient access to the inverted index data structure is a key aspect for a search engine to achieve fast response times to users’ queries . While the performance of an information retrieval (IR) system can be enhanced through the compression of its posting lists, there is little recent work in the literature that thoroughly compares and analyses the ...
Matteo Catena +2 more
openaire +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Memory Resident Parallel Inverted Index Construction [PDF]
, 2011 Advances in cloud computing, 64-bit architectures and huge RAMs enable performing many search related tasks in memory.We argue that term-based partitioned parallel inverted index construction is among such tasks, and provide an efficient parallel framework that achieves this task. We show that by utilizing an efficient bucketing scheme we can eliminate
Küçükyılmaz, Tayfun +2 more
openaire +3 more sources
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
Efficient Inverted Index Compression Algorithm Characterized by Faster Decompression Compared with the Golomb-Rice Algorithm. [PDF]
Entropy (Basel), 2021 Chmielowiec A, Litwin P.
europepmc +1 more source