Results 61 to 70 of about 6,761 (247)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Assessment and Experimental Validation of Grid-Forming Inverters’ Capability Counteracting Low-Frequency Oscillations

Applied Sciences
The integration of inverter-based resources (IBRs) is reshaping power grid operation by reducing system inertia, which impacts small-signal rotor angle stability and increases low-frequency oscillations (LFOs).
Markel Zubiaga, Ander Ordono, Alain Sanchez-Ruiz, Miren T. Bedialauneta, Paula Castillo   +4 more
doaj   +1 more source

Novel ZVS S-TCM Modulation of Three-Phase AC/DC Converters

IEEE Open Journal of Power Electronics, 2020
For three-phase AC-DC power conversion, the widely-used continuous current mode (CCM) modulation scheme results in relatively high semiconductor losses from hard-switching each device during half of the mains cycle.
Michael Haider, Jon Azurza Anderson, Spasoje Miric, Neha Nain, Grayson Zulauf, Johann W. Kolar, Dehong Xu, Gerald Deboy   +7 more
doaj   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Invertible definitions.

Notre Dame Journal of Formal Logic, 1987
This paper has two parts: A brief philosophical motivation followed by a technically complex development of conditions for certain types of definability. From some suggestion of P. Geach about when having the concept of one relation is to have the concept of another relation, the author characterizes the notion of informationally equivalent relations ...
openaire   +2 more sources

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Invert to Learn to Invert

, 2019
Iterative learning to infer approaches have become popular solvers for inverse problems. However, their memory requirements during training grow linearly with model depth, limiting in practice model expressiveness. In this work, we propose an iterative inverse model with constant memory that relies on invertible networks to avoid storing intermediate ...
Putzky, P., Welling, M.
openaire   +3 more sources

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Optimization of Compressor Preheating to Increase Efficiency, Comfort, and Lifespan

Technologies
Various compressors found in appliances such as air conditioners, refrigerators, dehumidifiers, etc., are gaining more popularity in different areas, including industry, retail, consumer electronics, and others.
Anton Dianov
doaj   +1 more source