Results 71 to 80 of about 41,214 (311)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Discrete Adaptive Nonswitching Reaching Law Algorithm for Sliding Mode Control of a Grid-Following Inverter

Energies
This paper extends one of the nonswitching-type reaching laws for discrete-time sliding mode control. The control task under consideration is the regulation of the grid current of the grid-following power inverter.
Albert Sawiński, Piotr Leśniewski, Piotr Chudzik   +2 more
doaj   +1 more source

A 12b-control ultra-low-power low-noise SC-VGA for medical ultrasound probes

The Journal of Engineering, 2013
This Letter presents a 12b-control ultra-low-power low-noise two-stage single-ended to differential switched-capacitor variable gain amplifier (SC-VGA) for 2–6-MHz second harmonic cardiac imaging ultrasound probes in 0.18 μm complementary metal oxide ...
Peng Wang, Thomas M. Halvorsrød, Trond Ytterdal   +2 more
doaj   +1 more source

Embedded EZ-Source Inverters [PDF]

, 2008
Z-source inverters are recent topological options proposed for buck-boost energy conversion with a number of possible voltage and current-type circuitries already reported in the literature.
Gao, F., Loh, Poh Chiang, F. Gao, F. Blaabjerg, P. Ch. Loh, Blaabjerg, Frede; id_orcid   +5 more
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

A Comparative Study Between Symmetrical and Asymmetrical Inverters [PDF]

, 2023
Inverters play a crucial role in modern power systems, converting direct current (DC) into alternating current(AC) for various applications. The choice between symmetrical and asymmetrical inverters can significantly impact system performance, efficiency,
Jamil, Mohsin, Hashmat, Ahmed Talal, Tajwar, Tahmid   +2 more
core   +1 more source

Implementing Wireless Charging System for Semi-Autonomous Agricultural Robots

Energies
The modernization of agriculture can help humanity address major challenges such as population growth, climate change, and labor shortages. Semi-autonomous agricultural robots offer clear advantages in automating tasks and improving efficiency.
Abdoulaye Bodian, Alben Cardenas, Dina Ouardani, Jaber Ouakrim, Afef Bennani-Ben Abdelghani   +4 more
doaj   +1 more source

Inverting non-invertible trees

, 2017
If a graph has a non-singular adjacency matrix, then one may use the inverse matrix to define a (labeled) graph that may be considered to be the inverse graph to the original one. It has been known that an adjacency matrix of a tree is non-singular if and only if the tree has a unique perfect matching; in this case the determinant of the matrix turns ...
Pavlíková, Soňa, Širáň, Jozef
openaire   +2 more sources

Analysis of Output Current Ripple of Three-phase PWM Inverter under Discontinuous Modulation Techniques [PDF]

, 2010
In this paper, an analysis of output current ripple of three-phase PWM inverters with discontinuous modulation is presented. The analytical expressions for discontinuous modulation injection signal are derived.
Dahono, Pekik Argo
core