Results 61 to 70 of about 7,194 (268)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Discrete Adaptive Nonswitching Reaching Law Algorithm for Sliding Mode Control of a Grid-Following Inverter

Energies
This paper extends one of the nonswitching-type reaching laws for discrete-time sliding mode control. The control task under consideration is the regulation of the grid current of the grid-following power inverter.
Albert Sawiński, Piotr Leśniewski, Piotr Chudzik   +2 more
doaj   +1 more source

Inverting non-invertible trees

, 2017
If a graph has a non-singular adjacency matrix, then one may use the inverse matrix to define a (labeled) graph that may be considered to be the inverse graph to the original one. It has been known that an adjacency matrix of a tree is non-singular if and only if the tree has a unique perfect matching; in this case the determinant of the matrix turns ...
Pavlíková, Soňa, Širáň, Jozef
openaire   +2 more sources

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Implementing Wireless Charging System for Semi-Autonomous Agricultural Robots

Energies
The modernization of agriculture can help humanity address major challenges such as population growth, climate change, and labor shortages. Semi-autonomous agricultural robots offer clear advantages in automating tasks and improving efficiency.
Abdoulaye Bodian, Alben Cardenas, Dina Ouardani, Jaber Ouakrim, Afef Bennani-Ben Abdelghani   +4 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Filling in the Gap of Eliminating CMV Spikes Under Low Modulation Indices in the SVM Three-Phase Inverters

IEEE Access
The high common-mode voltage (CMV) in two-level three-phase inverters will bring many negative effects. Many strategies are studied to reduce the CMV and eliminate the CMV spikes. However, due to the switching dead-time, there is a gap in eliminating CMV
Jin Huang, Kaicheng Li
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Improvement in the Energy Autonomy and the Mechanical Performances of an Onboard Actuation Chain for Robotics

Energies
This paper aims to improve the energy autonomy and the mechanical performances of an on-board drive chain for robotics. The energy autonomy improvement is performed by reducing electrical losses in the inverter.
Abdoul-Aziz Ahmed Hassan, Abderrezzak Cherifi, Ouahid Bouchhida, Sebastien Charles, Hassan Ali Barkad   +4 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source