Results 41 to 50 of about 727 (249)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Reduced-order dynamic model for droop-controlled inverter/converter-based low-voltage hybrid AC/DC microgrids – Part 2: DC sub-microgrid and power exchange

IET Smart Grid, 2018
This study focuses on reduced-order dynamical modelling of droop controlled converter-based DC sub-microgrid (MG) in a hybrid AC/DC MG. In hybrid MGs, electrical power is exchanged between the AC and DC sub-MGs by a bidirectional AC/DC converter.
Arsalan Rasoolzadeh, Farzad Rajaei Salmasi, Farzad Rajaei Salmasi   +2 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Architecture of urban rail transit power supply based on PET braking energy feedback

The Journal of Engineering, 2019
In recent years, the urban rail transit has a great development in many cities of China. It is important to keep the DC transit grid strong and the power transmitted/power transmission high quality.
Hao Liu, Zedong Zheng, Zheng Xu
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Stability analysis of distributed generation grid-connected inverter

The Journal of Engineering, 2019
With the distributed new energy power generation increased, the power grid system becomes more and more complex, leading to its stability more likely to be affected. Among them, the resonance caused by impedance mismatch is particularly critical.
Xuemei Zheng, Zhuang Liu, Chao Wang, Yidan Liu, Yong Feng   +4 more
doaj   +1 more source

Impact of advanced inverter functions on low‐voltage power grids

IET Energy Systems Integration, 2021
In today's power grid, a great number of inverter‐based distributed energy resources (DERs) are connected and are mainly designed to supply power without considering the voltage and frequency deviations of the grid.
Arjen Mentens, Harold R. Chamorro, Valéry Ann Jacobs, David Topolánek, Jiří Drápela, Wilmar Martinez   +5 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Research on the strategy of cooperative control between photovoltaic grid-connected and reactive power compensation technology

The Journal of Engineering, 2019
When connecting a large number of generating sets into power grid, there will be the harmonic wave generated in power grid causing voltage and current distortion, which affects power quality seriously.
Zhigang Li, Yalan Peng, Fang Yao, Mingyu Liu   +3 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source