Results 61 to 70 of about 968 (290)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

New multilevel inverter based on reduced switch basic cell for high voltage levels

IET Power Electronics
In this study, to solve total harmonic distortion (THD) and voltage stress on switches, challenges have been made by presenting a new multi‐level inverter (MLI). The proposed topology can operate with both symmetric and asymmetric sources.
Ali Seifi, Seyed Hossein Hosseini, Mehrdad Tarafdar Hagh, Majid Hosseinpour   +3 more
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Fault diagnosis for multiple current sensors in grid‐connected inverter based on average modulation voltage

IET Power Electronics
Grid‐connected inverters are the core equipment in the renewable power system. There are multiple current sensors which may affect the driving module of the switch in inverter.
Fan Zhang, Zhiwei Zhang, Guangfeng Jin, Tianzhen Wang, Jingang Han, Hubert Razik, Yide Wang   +6 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Analogue computer simulation of M.O.S. transistors [PDF]

, 1970
The physical expressions governing the operation of M.O.S.-devices are discussed and an analogue computer simulation of an enhancement M.O.S. transistor is given.
Dellow, Frank
core  

Power loss reduction in electronic inverters trough IGBT-MOSFET combination [PDF]

, 2009
This paper introduces a configuration aimed at switching losses reduction through a power leg constructed by combining a MOSFET and an IGBT. The combined use of these different switches leads to the turn-on losses reduction through the use of the faster ...
Angel Marinov, Valchev, Vencislav, Vencislav Valchev, Marinov, Angel   +3 more
core   +1 more source

Quasi‐Z‐source inverter with switched‐coupled‐capacitors

IET Power Electronics
This paper presents an improved switched‐inductor quasi‐Z‐source inverter with a higher boost factor than similar inverters, which integrates a switched‐capacitor and a three‐winding switched‐coupled inductor into a conventional quasi Z‐source inverter ...
Mohammad Hosein Babaei, Asghar Taheri, Jamal Abbasi Bolaghi, Masoumeh Gholami   +3 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

A novel virtual synchronous port control strategy for microgrid cluster

IET Renewable Power Generation
Interconnecting multiple microgrids (MGs) to form a MG cluster (MGC) is significant to improve the MG power supply reliability and increase the new energy accommodation capacity.
HongTao Shi, Jiaming Chang, Yuchao Li, Tingting Chen, Xiaolin Dong, Zhuoheng He   +5 more
doaj   +1 more source