Results 91 to 100 of about 23,565,951 (358)

Efficient investment in children [PDF]

If children are society’s most precious resource, as many would argue, how should we invest in them? To gain insight into this question, the authors develop a dynamic, general-equilibrium model in which children differ by ability. Parents invest time and
Anath Seshardi, Jeremy Greenwood, S. Rao Aiyagari   +2 more
core   +6 more sources

Assessment of soil erosion and its driving factors in the Huaihe region using the InVEST-SDR model

Geocarto International, 2023
Aiming to provide a scientific basis for the prevention and control of soil erosion in the Huaihe region, this study uses the InVEST-SDR model to estimate the temporal and spatial changes of soil erosion and soil conservation in the Huaihe region in 2010,
Ziqi Guo, Zhaojin Yan, MiErZhaTi PaErHaTi, Rong He, Hui Yang, Ran Wang, Hui Ci   +6 more
doaj   +1 more source

Multi-asset minority games [PDF]

, 2006
We study analytically and numerically Minority Games in which agents may invest in different assets (or markets), considering both the canonical and the grand-canonical versions.
Bianconi, Ginestra, De Martino, Andrea, Ferreira, Felipe F., Marsili, Matteo   +3 more
core   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Habitat quality assessment of mining cities based on InVEST model—a case study of Yanshan County, Jiangxi Province

, 2022
The assessment of the spatiotemporal evolution of habitat quality caused by land use changes can provide a scientific basis for the ecological protection and green development of mining cities. Taking Yanshan County as an example of a typical mining city,
Yanan Li, L. Duo, M. Zhang, Jingyuan Yang, Xiaofei Guo   +4 more
semanticscholar   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Temporal and Spatial Evolution and Driving Force Analysis of Water Conservation Function in Yunnan Province Based on Climate and Land Use Change

Shuitu Baochi Xuebao
[Objective] Exploring the water-holding function is an important way to cope with future climate change. Existing research mainly focuses on the assessment of historical and current water-holding function, and lacks the understanding of the future water ...
LIU Fengru, ZHAO Junsan, LIN Yilin, CHEN Guoping, ZHANG Longjiang, PENG Sufen   +5 more
doaj   +1 more source

Opzioni reali e Investimenti in Ricerca e Sviluppo [PDF]

This paper combines the real options approach with game theory in order to evaluate the convenience to invest in Research and Development (R&D). The evaluation method adopted in this case is not based on the traditional $VAN$ but on the binomial model ...
Rosalba Padalino
core