Results 81 to 90 of about 1,387,394 (314)
Insights into a long life without cancer: The case of the bowhead whale
Molecular Oncology, EarlyView.Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley +1 more source
Shuitu Baochi Xuebao[Objective] This paper aims to deepen the understanding of the carbon cycle by analyzing the spatiotemporal evolution characteristics of carbon storage in the central Yunnan urban agglomeration and its response to land use/land cover (LULC) change, so as
PENG Shuangyun +4 more
doaj +1 more source
The Effect of Entry on R&D Investment of Leaders: Theory and Empirical Evidence [PDF]
We develop a simple model of competition for the market that shows that, contrary to the Arrow view, endogenous entry threat in a market induces the average firm to invest less in R&D and the incumbent leader to invest more.
Czarnitzki, Dirk +2 more
core
Molecular cancer prevention: Intercepting disease
Molecular Oncology, EarlyView.Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco +2 more
wiley +1 more source
Shuitu Baochi Xuebao[Objective] Through the spatio-temporal dynamic analysis of landscape ecological pattern and habitat quality, the response of habitat quality before and after the implementation of soil and water conservation measures in PU River Basin of Shenyang City ...
LIU Jiayi, XU Dawei, XU Jia
doaj +1 more source
Stock options and managerial incentives to invest [PDF]
We examine the effect of stock options on managerial incentives to invest. Our chief innovation is a model wherein firm value and executive decisions are endogenous.
Nohel, Tom, Steven Todd
core
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Spatial Response of Habitat Quality to Climate Change and Human Activities
Shuitu Baochi Xuebao[Objective] To explore the dynamic changes in the environmental quality of the Qinghai-Xizang Plateau and provide reference for ensuring the ecological security of the Qinghai-Xizang Plateau, protecting biodiversity and building a strong ecological ...
JIA Tianchao +3 more
doaj +1 more source
Investing at home and abroad: different costs, different people? [PDF]
, 2009 We investigate US households’ direct investment in stocks, bonds and liquid accounts and their foreign counterparts, in order to identify the different participation hurdles affecting asset investment domestically and overseas. To this end, we estimate a
Christelis, Dimitris +1 more
core
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source