Results 71 to 80 of about 141,317 (267)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Spatiotemporal Evolution of Carbon Storage in the Central Yunnan Urban Agglomeration and Its Response to LULC Change

Shuitu Baochi Xuebao
[Objective] This paper aims to deepen the understanding of the carbon cycle by analyzing the spatiotemporal evolution characteristics of carbon storage in the central Yunnan urban agglomeration and its response to land use/land cover (LULC) change, so as
PENG Shuangyun, CHEN Mingxiao, ZHANG Laowei, GONG Luping, FAN Jiajun   +4 more
doaj   +1 more source

Stochastic Models of Capital Investment

Journal of the Royal Statistical Society Series B: Statistical Methodology, 1969
Summary An asset generates profits of random amounts at random points in time. We discuss the distribution theory of total profits for a given period under discounting and reinvestment. The problem of replacement is also considered. An application of the results is made to Premium Savings Bonds.
openaire   +2 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Analysis of Landscape Patterns and Spatio-temporal Evolution of Habitat Quality in the PU River Basin Based on the InVEST Model

Shuitu Baochi Xuebao
[Objective] Through the spatio-temporal dynamic analysis of landscape ecological pattern and habitat quality, the response of habitat quality before and after the implementation of soil and water conservation measures in PU River Basin of Shenyang City ...
LIU Jiayi, XU Dawei, XU Jia
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Spatial–temporal differentiation law of habitat quality and its driving mechanism in the typical plateau areas of the Loess Plateau in the recent 30 years

Open Geosciences
The Dongzhi Plateau, the largest remaining loess tableland on the Chinese Loess Plateau, is a critical region within the Yellow River Basin, and its ecological health is vital for regional ecological security and sustainable development.
Zhao Xingping, Li Wendong, Wang Peng, Liu Mengmeng, Jiang Chengcheng, Yu Ningyu   +5 more
doaj   +1 more source

Spatial Response of Habitat Quality to Climate Change and Human Activities

Shuitu Baochi Xuebao
[Objective] To explore the dynamic changes in the environmental quality of the Qinghai-Xizang Plateau and provide reference for ensuring the ecological security of the Qinghai-Xizang Plateau, protecting biodiversity and building a strong ecological ...
JIA Tianchao, HU Xiwu, YANG Haijuan, GUO Wei   +3 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source