Results 71 to 80 of about 1,387,394 (314)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Opzioni reali e Investimenti in Ricerca e Sviluppo [PDF]

This paper combines the real options approach with game theory in order to evaluate the convenience to invest in Research and Development (R&D). The evaluation method adopted in this case is not based on the traditional $VAN$ but on the binomial model ...
Rosalba Padalino
core  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Temporal and Spatial Evolution and Driving Force Analysis of Water Conservation Function in Yunnan Province Based on Climate and Land Use Change

Shuitu Baochi Xuebao
[Objective] Exploring the water-holding function is an important way to cope with future climate change. Existing research mainly focuses on the assessment of historical and current water-holding function, and lacks the understanding of the future water ...
LIU Fengru, ZHAO Junsan, LIN Yilin, CHEN Guoping, ZHANG Longjiang, PENG Sufen   +5 more
doaj   +1 more source

Explaining persistent cycles in a short-run context: firms’ propensity to invest and omnipotent shareholders [PDF]

In this article, we develop a standard short-run Kaleckian macromodel. First, we study the stability of equilibrium and make some comparative static exercises. Then, we take into account different specifications for an endogenous propensity to invest and
Charles, Sébastien
core   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Predicting the aesthetic impact of wind turbines and their influence on landscape value

TeMA: Journal of Land Use, Mobility and Environment
The growing reliance on renewable energy sources (RES) is a direct response to global challenges such as climate change and the limited availability of fossil fuels.
Shiva Rahmani, Pierri Vito, Luigi Zuccaro, Beniamino Murgante   +3 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Capital Flows to Developing Countries: The Allocation Puzzle [PDF]

The textbook neoclassical growth model predicts that countries with faster productivity growth should invest more and attract more foreign capital.
Olivier Jeanne, Pierre-Olivier
core  

Stochastic Models of Capital Investment

Journal of the Royal Statistical Society Series B: Statistical Methodology, 1969
Summary An asset generates profits of random amounts at random points in time. We discuss the distribution theory of total profits for a given period under discounting and reinvestment. The problem of replacement is also considered. An application of the results is made to Premium Savings Bonds.
openaire   +2 more sources