Results 81 to 90 of about 25,640,457 (357)

The Effect of Entry on R&D Investment of Leaders: Theory and Empirical Evidence [PDF]

We develop a simple model of competition for the market that shows that, contrary to the Arrow view, endogenous entry threat in a market induces the average firm to invest less in R&D and the incumbent leader to invest more.
Czarnitzki, Dirk, Etro, Federico Gabriele, Kraft, Kornelius   +2 more
core   +3 more sources

Spatiotemporal Evolution and Future of Carbon Storage in Resource-Based Chinese Province: A Case Study from Shanxi Using PLUS–InVEST Model Prediction

Sustainability
Resource exploitation markedly alters land use and ecological carbon storage, posing risks to carbon sinks and food security. This study analyzes land-use change from 1990 to 2020 in the resource-based province of Shanxi, China.
Yuhua Jiao, Yuhui Wang, Chenghong Tu, Xuen Hou, Chunjuan Lyu, Xiang Fan, Lu Xia   +6 more
semanticscholar   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Carbon Dynamics in the Northeastern Qinghai–Tibetan Plateau from 1990 to 2030 Using Landsat Land Use/Cover Change Data

Remote Sensing, 2020
Land use/cover change (LUCC) has an important impact on the terrestrial carbon cycle. The spatial distribution of regional carbon reserves can provide the scientific basis for the management of ecosystem carbon storage and the formulation of ecological ...
Jingye Li, Jian Gong, Jean-Michel Guldmann, Shicheng Li, Jie Zhu   +4 more
doaj   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Multi-asset minority games [PDF]

, 2006
We study analytically and numerically Minority Games in which agents may invest in different assets (or markets), considering both the canonical and the grand-canonical versions.
Bianconi, Ginestra, De Martino, Andrea, Ferreira, Felipe F., Marsili, Matteo   +3 more
core   +1 more source

Effects of land-use and climate change on sediment and nutrient retention in Guizhou, China

Ecosystem Health and Sustainability, 2020
Introduction  Sediment and nutrient retention have significant impacts on agricultural productivity and water quality. Obvious changes of climate and land-use have deeply affected freshwater ecosystem services in the last several decades.
Huiqing Han, Jianqiang Yang, Geng Ma, Yue Liu, Linan Zhang, Siying Chen, Shuliang Ma   +6 more
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Efficient investment in children [PDF]

If children are society’s most precious resource, as many would argue, how should we invest in them? To gain insight into this question, the authors develop a dynamic, general-equilibrium model in which children differ by ability. Parents invest time and
Anath Seshardi, Jeremy Greenwood, S. Rao Aiyagari   +2 more
core   +6 more sources

Spatio-Temporal Evolution and Multi-Scenario Prediction of Ecosystem Carbon Storage in Chang-Zhu-Tan Urban Agglomeration Based on the FLUS-InVEST Model

Sustainability
Land use/land cover change has a significant indicative effect on the carbon storage of terrestrial ecosystems. We selected Chang-Zhu-Tan urban agglomeration as the research object, coupled FLUS and InVEST models to explore the changes in land use and ...
Weiyi Sun, Xianzhao Liu
semanticscholar   +1 more source