Results 91 to 100 of about 4,038,876 (172)
Alimentary Pharmacology &Therapeutics, EarlyView.In this nationwide ENEIDA registry study, anti‐TNF therapy after prior exposure to a different biologic mechanism of action showed reduced treatment durability in inflammatory bowel disease, with a particularly marked impact in ulcerative colitis, where short‐ and long‐term clinical effectiveness was also lower. ABSTRACT Background The expanding use of
Carmen Yagüe Caballero +85 more
wiley +1 more source
Alimentary Pharmacology &Therapeutics, EarlyView.The HLA‐A*11:01 allele is associated with persistent viraemia and advanced liver fibrosis in HDV infection. HLA‐A*11:01 carriers exhibit a reduced T‐cell repertoire, suggesting a narrower T‐cell response to the infection. ABSTRACT Background Hepatitis delta virus (HDV) infection causes the most severe form of viral hepatitis, with highly heterogeneous ...
Maria Francesca Cortese +11 more
wiley +1 more source
Automatic magnetic resonance imaging series labelling for large repositories
Journal of Big DataLarge medical image repositories present challenges related to unstructured data. A data enrichment process allows the storage of additional information for fast identification of the content and properties of medical imaging studies.
Armando Gomis-Maya +8 more
doaj +1 more source
Survival outcomes and treatment patterns in myelofibrosis in the JAK inhibitor era
British Journal of Haematology, EarlyView.Summary Data on real‐world survival and treatment patterns in large, unselected myelofibrosis (MF) cohorts remain limited. We analysed 1649 patients with MF diagnosed from 2010 onwards and included in the Spanish Myelofibrosis Registry across 64 centres. Janus kinase (JAK) inhibitors were administered to approximately half of the patients.
Juan‐Carlos Hernández‐Boluda +35 more
wiley +1 more source
Biology of Sex DifferencesBackground Early-life stress constitutes a major risk factor for the development of neuropsychiatric and substance use disorders, exerting enduring effects on stress responsivity and emotional behavior.
Laura Sánchez-Marín +8 more
doaj +1 more source
British Journal of Haematology, EarlyView.Summary While the majority of myeloid neoplasms are sporadic, the increasing application of germline genetic testing has led the World Health Organization to designate ‘Myeloid malignancies with germline predisposition’ as a distinct clinical entity, carrying major implications for clinical care and research.
Elena Vuelta +9 more
wiley +1 more source
Brain Pathology, EarlyView.Integrated histological and transcriptional profiling of the glioblastoma periphery reveals clinically relevant tumor infiltration beyond MRI‐defined boundaries. MRI‐guided biopsies from contrast‐enhancing (CE), non‐contrast‐enhancing (nCE), edema (E), and radiologically normal (N) regions demonstrate that nCE areas frequently retain neoplastic and ...
Olaya de Dios +18 more
wiley +1 more source
Herramientas para impulsar la investigación en el ámbito hospitalario
NURE Investigación, 2012 Curriculum: Licenciada en Antropología Social y Cultural y Diplomada en Enfermería. Técnico de apoyo a la investigación de la Fundación para la Investigación Biomédica del Hospital Ramón y Cajal.
Alejandra Cano Arana
doaj
Automated identification of MRI series using a hierarchical modular machine-learning pipeline
European Radiology ExperimentalObjective The volume and diversity of large MR imaging datasets require efficient automated labelling tools for cataloguing MR series, as manual annotation is impractical and costly.
Mariusz J. Kujawa +4 more
doaj +1 more source
British Journal of Pharmacology, EarlyView.Abstract Opioids are prescribed widely for chronic pain despite well‐recognised risks and variable long‐term benefit, reflecting the lack of effective alternatives for many patients. Combination therapies offer a promising strategy to enhance efficacy whilst reducing side effects.
André Mouraux +26 more
wiley +1 more source