Results 111 to 120 of about 743,546 (262)

Relief of pain associated with spasticity in adult patients after treatment with onabotulinumtoxinA: Post hoc observational results from the ASPIRE study

PM&R, EarlyView.
Abstract Background Pain is often observed in patients with spasticity, but little is known about the relationship between pain and spasticity and the effectiveness of treating pain with botulinum toxins in these patients. Objective To explore onabotulinumtoxinA (onabotA) use and pain relief in patients with spasticity with pain at baseline.
Jörg Wissel, Cassandra List, Marc Schwartz, Mariana Nelson, Tiziana Musacchio, Esther Duarte   +5 more
wiley   +1 more source

Neuraminidase-activated microglia compromise the viability of ependymocytes [PDF]

, 2017
Neuraminidase (NA) is a sialidase present in the envelope/wall of some virus/bacteria responsible for brain infections, such as flu, mumps or meningitis. The intracerebroventricular injection of NA in the rat brain provokes ependymal detachment and death,
Carrillo-Pinzon, Cristobal, Fernandez-Arjona, Mar, Fernández-Llebrez, Pedro, Grondona, Jesús M, López-Ávalos, María Dolores   +4 more
core  

Use of the terms "Wellbeing" and "Quality of Life" in health sciences: A conceptual framework [PDF]

, 2014
Background and Objectives: The assessment of wellbeing is a top priority in health sciences. The aim of this paper is to review the history of the concept of wellbeing and “Quality of Life” (QoL), and to understand the theories and assumptions that ...
Ayuso Mateos, José Luis, Lucas, Ramona, Miret, Marta, Salvador-Carulla, Luis   +3 more
core   +4 more sources

Titanium Detected in Liver, Kidney, Spleen, and Intestine Is Not Related to Dose, Time, or Route of Exposure to Titanium Dioxide: A Systematic Review

Environmental Toxicology, EarlyView.
ABSTRACT Titanium dioxide (TiO2), used as a food additive (labeled E171 in Europe), was withdrawn from the European market in 2022. The E171 toxicity mechanism involves its uptake, oxidative stress, DNA damage, and inflammation. It has been hypothesized that the TiO2 accumulation nanoparticles (NPs) or E171 triggers tissue damage, and some studies have
Carmen Ximena Martínez‐Escutia, Estefany I. Medina‐Reyes, Eduardo Delgado‐Armenta, Yolanda I. Chirino   +3 more
wiley   +1 more source

Influence of ATG SNPs on hip fracture patients’ functional status

Scientific Reports
One of the key factors influencing the prognosis of older patients with hip fracture is their previous functional status. Autophagy has been related to bone disease and to osteoporosis onset. Some studies have analyzed the relationship of certain genetic
Carmen da Casa, Carlos Gutiérrez-Cerrajero, Carmen Pablos, M. Agustina Hierro-Estévez, Alfonso González-Ramírez, David Briz, Rogelio González-Sarmiento, Juan F. Blanco   +7 more
doaj   +1 more source

Galanin decreases NPYY1R internalization and β- Arrestin2 recruitment [PDF]

, 2015
We have recently described a Galanin receptor 2(GALR2) and Neuropeptide Y Y1 receptor(NPYY1R) interaction at behavioural, cellular and receptor levels through GALR2/NPYY1R heterodimers.
Borroto-Escuela, Dasiel, Díaz-Cabiale, Zaida, Flores-Burgess, Antonio, Fuxe, Kjell, Gago, Belén, Millón, Carmelo, Narváez, José Ángel, Narváez, Manuel, Santin-Nuñez, Luis Javier   +8 more
core  

Genomic analyses of microdissected Hodgkin and Reed-Sternberg cells: mutations in epigenetic regulators and p53 are frequent in refractory classic Hodgkin lymphoma [PDF]

, 2019
This work was supported by grants from the Plan Nacional de I + D + I cofinanced by the ISCIII-Subdirección General de Evaluación and the Fondo Europeo de Desarrollo Regional (FEDER), PI12/1832, the Spanish Association for Cancer Research (AECC), and ...
Astudillo, Aurora, Estévez, Mónica, Fernández, Rubén, Fernández, Sara, García, Juan F., García-Cosío, Mónica, Mata, Elena, Montalbán, Carlos, Piris, Miguel A., Provencio Pulla, Mariano, Provencio, Mariano, Sánchez-Beato, Margarita   +11 more
core   +2 more sources

Effects of Tributyltin Chloride on Human Neuronal Differentiation and Mice Brain Development

Environmental Toxicology, EarlyView.
ABSTRACT According to the developmental origins of health and disease hypothesis, perinatal exposure to an environmental toxicant during the development of the nervous system could cause a permanent cellular modification that may promote the appearance of neurodegenerative diseases at an older age.
Ester López‐Gallardo, Patricia Meade, Irene Jiménez‐Salvador, Carmen Hernández‐Ainsa, Eldris Iglesias, Alba Pesini, Nuria Garrido‐Pérez, Sonia Emperador, David Pacheu‐Grau, Pilar Bayona‐Bafaluy, Eduardo Ruiz‐Pesini   +10 more
wiley   +1 more source

Una evaluación crítica de la relación entre la industria alimentaria y la investigación en salud

Gaceta Sanitaria, 2017
Objetivo: Describir la influencia de las corporaciones alimentarias en los resultados de la investigación en salud. Método: Revisión sistemática en MedLine, Cochrane Library Plus y Scopus usando los MESH “Food Industry”, “Food-Processing Industry ...
Josep León Mengíbar, María Pastor-Valero, Ildefonso Hernández Aguado   +2 more
doaj   +1 more source

Neuropathological events in an animal model resembling human fetal post-hemorrhagic hydrocephalus [PDF]

, 2019
Introduction: In premature newborns, intraventricular hemorrhages (IVH) probably trigger the disruption of the neurogenic ventricular zone. Most of the cases with severe IVH develop post-hemorrhagic hydrocephalus (PHH).
Jimenez-Lara, Antonio Jesus, Ojeda-Pérez, Betsaida, Páez-González, Patricia   +2 more
core