Results 151 to 160 of about 4,038,876 (172)
Cardioprotective hormone relaxin‐2 showed relevant effects on rat skeletal muscle by altering proteins linked to muscle function, regeneration, differentiation, mitochondrial function, glucose metabolism, and structural integrity and organization. Specifically, relaxin‐2 reduced the expression of 95 proteins, increased 32, and elicited unique proteins ...
Xocas Vázquez‐Abuín +11 more
wiley +1 more source
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Highly water‐soluble dicationic bis(indolium) dyes have been prepared, showing excellent two‐photon absorption and light emission. Their fluorescence behavior discloses an unusual increasing blue shift with increasing solvent polarity, which, in parallel, is beneficial for enhanced detection in biological media.
Carlos Benitez‐Martin +5 more
wiley +1 more source
Bioorthogonal chemistry was applied to intracellularly photoactivate Doxorubicin (Dox) using gold nanostars (AuNSt) and near‐infrared (NIR) light. Two prodrugs were used: one photoactivatable, masked with 2‐nitrobenzyl carbamate (proDox1) and another photolabile, masked with 2‐nitrobenzyl diol (proDox2), which was attached to the AuNSt surface.
Juan José Esteve‐Moreno +15 more
wiley +1 more source
Programming of Complex Magnetic Profiles Enforced by 4D Printed Magnetic LCE Actuators
A 4D printing‐enabled magnetic programming strategy is introduced in which thermally actuated liquid crystal elastomers are magnetized in their target shape to encode complex three‐dimensional magnetic profiles. The resulting actuators achieve multistate shape morphing and programmable locomotion under low magnetic fields, without requiring specialized
Erick R. Espíndola‐Pérez +5 more
wiley +1 more source
Secular Trend in Age at Menarche and Associated Determinants in the Valencian Population (Spain)
The graphical abstract illustrates changes in age at menarche in the Valencian population (Spain) over nearly eight decades and its association with anthropometric and sociodemographic factors. ABSTRACT Objective To assess secular trend in age at menarche spanning nearly eight decades and to explore variations in these patterns according to selected ...
Andrea Beneito +11 more
wiley +1 more source
Unveiling the Functional Role of KIF21B in Microglia Inflammatory Response
Microglia express KIF21B in both sexes. KIF21B binds to microglia cytoskeleton; inflammation alters such interaction promoting a phagocytic state in females. In male microglia KIF21B modulates migration. ABSTRACT Microglia are brain immune cells that maintain homeostasis and respond to injury, changing cell morphology to drive inflammation, migration ...
Danny Ganchala +6 more
wiley +1 more source
Abstract Relapsed/refractory (R/R) B‐cell lymphomas (B‐NHL) remain incurable, with limited predictive biomarkers to guide immunotherapy. Preclinical platforms that faithfully preserve the immune context and the viability of patient samples are critically needed for relevant high‐throughput drug testing.
Fabien Gava +20 more
wiley +1 more source
Abstract Waldenström macroglobulinemia (WM) and IgM monoclonal gammopathy of undetermined significance (MGUS) share the same cell of origin but differ in clonal size. Compared with other B‐cell neoplasms, the lymphoplasmacytic clone in WM can be rather small, limiting our understanding of clonal expansion.
David F. Moreno +22 more
wiley +1 more source
ABSTRACT Viral infections during critical periods of pregnancy trigger inflammatory responses that alter offspring brain development and behavior, resulting in psychiatric disorder‐associated phenotypes. This condition is commonly referred to as prenatal stress induced by maternal immune activation (MIA).
Johaly Anguiano‐Buenfil +4 more
wiley +1 more source

