Results 161 to 170 of about 110,805 (249)

MGL‐Based Drug Conjugate: A Novel Glycan‐Targeting Strategy for Potential Precision Cancer Therapy

ChemistryEurope, Volume 4, Issue 5, May 2026.
An engineered macrophage galactose‐type lectin (MGL)‐based conjugate (mMGL‐vcMMAE), incorporating an exposed cysteine for site‐specific drug linkage, preserves stability, binding profile, and affinity of the native MGL carbohydrate recognition domain. It also selectively targets Tn/STn‐expressing cancer cells and shows recognition of colorectal cancer ...
Carlos D. L. Lima, Rafaela Abrantes, Victor Lorrain, Joana Gomes, Reyes Núñez‐Franco, João P. M. António, Catarina Gomes, Ana Gimeno, Benedita A. Pinheiro, Angelina S. Palma, Jesús Jiménez‐Barbero, Pedro M. P. Gois, Gonzalo Jiménez‐Osés, Sandra J. van Vliet, Celso A. Reis, Filipa Marcelo   +15 more
wiley   +1 more source

Randomized double-blind clinical trial evaluating the effectiveness and safety of secondary prophylaxis with oral vancomycin versus placebo in the prevention of recurrence of <i>clostridioides difficile</i> infection in patients receiving systemic antibiotic therapy (PREVAN trial). [PDF]

JAC Antimicrob Resist
San-Juan R, Origüen J, Fernández-Ruiz M, Campion K, Silva JT, López-Medrano F, Villa J, Díaz-Pollan B, Callejas-Díaz A, Candela G, Boan J, Aparicio-Minguijon E, Asin MAP, Rodriguez-Goncer I, Martín-Arriscado C, Ferrari JM, Aguado JM.   +16 more
europepmc   +1 more source

Hair Cortisol Concentrations in Children: A Longitudinal Analysis Across Childhood

Developmental Psychobiology, Volume 68, Issue 3, May 2026.
ABSTRACT Hair cortisol concentration (HCC) reflects long‐term cortisol exposure and is commonly used as a biomarker of hypothalamic–pituitary–adrenal axis activity. Although increasingly applied in pediatric populations, developmental changes in HCC and potential sex differences remain unclear.
Miguel Ángel Baos‐González, Javier De Echarri‐Lorente, María Ángeles García‐León, Raquel González‐Pérez, María Isabel Peralta‐Ramírez   +4 more
wiley   +1 more source

Impact of seasonal temperature variations on adverse outcomes in atrial fibrillation: comparative insights from Vigo and Murcia cohorts. [PDF]

J Glob Health
Soler-Espejo E, Ramos-Bratos MP, González-Bermúdez I, Rivera-Caravaca JM, Domínguez-Erquicia P, Íñiguez-Romo A, Marín F, Roldán V, Raposeiras-Roubín S.   +8 more
europepmc   +1 more source

A Hybrid Nonparametric Framework for Outlier Detection in Functional Time Series

Environmetrics, Volume 37, Issue 4, May 2026.
ABSTRACT Outlier detection in functional time series is challenging due to temporal dependence and the simultaneous presence of magnitude, shape, and partial anomalies. Existing methods often assume independence or rely on model based approaches, such as the Standard Smoothed Bootstrap on Residuals (SmBoR), which may not work well if the model is ...
David Solano, Ruben Dario Guevara, Sergio A. Calderón V., Marc Saez, Maria A. Barceló   +4 more
wiley   +1 more source

Heparan Sulphate Glycosaminoglycan Chains Contribute to the Tethering of Coronal Factors and Are Important for Extracellular Vesicle‐Mediated Fibroblast Activation

Journal of Extracellular Biology, Volume 5, Issue 5, May 2026.
ABSTRACT Extracellular vesicles (EVs) play a critical role in intercellular communication, yet the contribution of the EV corona and associated surface structures, such as heparan sulphate glycosaminoglycan (HS GAG) chains, to EV function remains poorly understood.
Sara Veiga, Alex P. Shephard, Kate Milward, Alex Cocks, Félix Royo, Juan M. Falcon‐Perez, Aled Clayton, Jason P. Webber   +7 more
wiley   +1 more source

Helicobacter pylori Eradication Primary Care First-Line Prescriptions: Data From 200,000 Patients in a Real-World Cohort. [PDF]

Helicobacter
Fernández-Antón E, P Nyssen O, Alonso-Martínez G, Parra P, Gil M, P Gisbert J, de Abajo FJ.   +6 more
europepmc   +1 more source

Comparative Analysis of Dietary Patterns in Children With Phenylketonuria Phenotypes and Controls: Implications for Nutritional Status

Journal of Inherited Metabolic Disease, Volume 49, Issue 3, May 2026.
ABSTRACT Individuals with phenylketonuria (PKU), caused by different variants of the phenylalanine hydroxylase gene, need to restrict their intake of phenylalanine. This study evaluated dietary patterns and physical activity levels in children with different PKU phenotypes compared to healthy controls. Eighty‐two children were recruited (22 classic PKU
Dolores Garcia‐Arenas, Aida Ormazabal, Paula Isern, Blanca Barrau‐Martinez, Arnau Gonzalez‐Rodriguez, Alba Tor‐Roca, Rafael Llorach, Jaume Campistol‐Plana, Mireia Urpi‐Sarda, Consortium PKU.cat.   +9 more
wiley   +1 more source

Hidradenitis suppurativa in patients with inflammatory bowel disease: a national multicenter study from the GETECCU-ENEIDA Registry. [PDF]

Ther Adv Gastroenterol
Madero-Velázquez L, de Francisco R, Herreros B, Yagüe C, Bujanda L, Calvet X, Ponferrada A, Aguas M, Rodríguez-Moranta F, Marín-Jiménez I, Catalá L, Gargallo-Pueyo C, Huguet J, Mesonero F, Monfort D, Sierra-Ausín M, Igualada L, Ricart-Gomez E, González-Vivo M, García MJ, Camba AH, Elorza A, Zabalza-San Martín L, Ramos L, Martín-Arranz MD, Ruiz-Núñez I, Martínez-Montiel P, Soto P, Roig C, Molina M, Mañosa M, Alba C, Barreiro-de Acosta M, Gisbert JP, Ramírez de la Piscina P, Lorente R, Zabana Y, Botella B, Riestra S, Belen-Galipienso O, Busquets D, Argüelles F, Pascual JC, Zapater P, Domènech E, Gutiérrez A.   +45 more
europepmc   +1 more source

Readiness Level of Spanish Labs to Detect Mpox Clade Ib: A Nationwide EQA

Journal of Medical Virology, Volume 98, Issue 5, May 2026.
ABSTRACT To assess the preparedness and diagnostic capacity of Spanish clinical microbiology laboratories to detect the emerging monkeypox virus (MPXV) Clade Ib through a nationwide external quality assessment. A blinded 16‐sample panel (serum and DNA eluates) containing MPXV Clade Ib, Clade II, vaccinia, and negatives was distributed.
Adolfo De Salazar, Anabel Negredo, Juan Carlos Galán, Teresa Del Peso, Marta Illescas, Laura Martínez‐García, Concepción Gimeno, Federico García, María Paz Sánchez‐Seco, the QC Mpox Spain Collaborators, Sonia Algarate, Andrés Antón, Ana Milagro, Fernando Buñuel, Laura Calatayud, Pilar Catalán, Gregorio Marañón, Marta Domínguez‐Gil González, Manel Flores, Pablo Fraile, Ana Fuentes López, María del Carmen Garma, Mª Dolores Gómez‐Ruíz, Mónica Gozalo, Manuel Grau, Almudena Gutiérrez‐Arroyo, Silvia Hernáez, Águeda Hernández‐Rodríguez, Noelia Hernando, Flor Isabel Hidalgo, José Luis Juan, Eduardo Lagarejos, Miguel Julián Martínez‐Yoldi, Santiago Melón, Pablo Mendoza, Laura Merino, Milagrosa Montes, Jordi Niubó, María Dolores Ocete, Alejandra Pérez‐García, Jorge Alfredo Pérez‐García, Mercedes Pérez‐Ruiz, Sonia Pérez‐Castro, Jordi Reina, Romina Soledad Romero, Genoveva Santillana, Encarna Simarro, Mikel Urruticoechea, Laura Herrero, Francisca Molero   +49 more
wiley   +1 more source