Results 201 to 210 of about 743,546 (262)

The Gut Microbiota as a Mediator in the Relationship Between Dietary Patterns and Depression

MedComm, Volume 7, Issue 2, February 2026.
Healthy dietary patterns are associated with gut microbial genera linked to lower depressive symptoms. In 644 older adults from the PREDIMED‐Plus cohort, 16S rRNA sequencing and dietary scoring revealed that taxa associated with a better diet quality were also more abundant in individuals with fewer depressive symptoms.
Adrián Hernández‐Cacho, Jiaqi Ni, Jesús F. García‐Gavilán, Prokopis Konstanti, Clara Belzer, Jesús Vioque, Dolores Corella, Montserrat Fitó, Josep Vidal, Laura Torres‐Collado, Oscar Coltell, Nancy Babio, Javier Hernando‐Redondo, Isabel Moreno‐Indias, Miguel Ruiz‐Canela, Francisco J. Tinahones, Jordi Salas‐Salvadó   +16 more
wiley   +1 more source

Design, Synthesis, and Evaluation of Naphthyl Pyrazino‐Pyrido‐Pyrimidinones Targeting the Phosphoinositide 3‐Kinase/Alpha‐Serine/Protein Kinase B/Mammalian Target of Rapamycin Pathway

ChemistryOpen, Volume 15, Issue 2, February 2026.
Rationally designed naphthyl pyrazino‐pyrido‐pyrimidinones 3 and 4 inhibited 85%–94% of cancer cell growth. Compound 4 exhibited IC50 = 7.8–12.8 µM with tumor selectivity. Both induced G1 arrest and modulated ULK1, STAT3, alpha‐serine/protein kinase B (AKT), and autophagy via phosphoinositide 3‐kinase/mammalian target of rapamycin (PI3K/mTOR ...
Marcelo F. Marchiori, Gabriel da Silva, Daniel F. Kawano, Andréia M. Leopoldino, Enrique Madruga, Ana Martinez, Ivone Carvalho   +6 more
wiley   +1 more source

Revisión sobre el papel de la filantropía en investigación e innovación biomédica [PDF]

, 2014
Bigorra, Joan, Bosch, Fèlix, Esteve, Josep   +2 more
core  

Comparative Study on the Management and Outcomes of Postoperative Crohn's Disease in Older Patients: Data From the ENEIDA Registry

United European Gastroenterology Journal, Volume 14, Issue 1, February 2026.
ABSTRACT Background Limited data are available on the management and outcomes of postoperative Crohn's disease (CD) in older patients. We aimed to describe the management of CD in the postoperative setting and assess surgical postoperative recurrence (POR) in this population.
Míriam Mañosa, Margalida Calafat, Elena Ricart, Pilar Nos, Eva Iglesias, Sabino Riestra, Francisco Mesonero, Marta Calvo, Jordi Guardiola, Vicent Hernández, Montserrat Rivero, Daniel Carpio, Miguel Mínguez, Cristina Alba, Maria Dolores Martín‐Arranz, Milagros Vela, Fernando Gomollón, Santiago García‐López, Ana Gutiérrez Casbas, Xavier Calvet, Carlos González‐Muñoza, Jesús Barrio, Javier P. Gisbert, Beatriz Sicilia, José Lázaro Pérez‐Calle, Luis Bujanda, Maria Esteve, Laura Ramos, Pilar Varela, Mónica Sierra, Olga Merino, Fernando Bermejo, Manuel Barreiro‐de Acosta, Antonio Rodríguez Perez, Lucía Márquez‐Mosquera, Orlando García‐Bosch, Iago Rodríguez‐Lago, Rufo H. Lorente Poyatos, Mariana Fe García Sepulcre, Nuria Maroto, Pablo Vega, David Monfort, Lucía Zabalsa San Martín, David Busquets, Pilar Martinez‐Montiel, Joan Riera, Guillermo Alcain, Jordina Llaó, Nacho Marin, Ignacio Marin‐Jimenez, Eva Sesé, Manuel Van Domselaar, José M° Huguet, Daniel Ginard, Francesc Bas‐Cutrina, Yolanda Ber, Oscar Roncero, Alfredo J. Lucendo, Alicia López‐García, Margarita Menacho, Pedro Almela, Ángel Ponferrada, Ana Fuentes Coronel, Sergio Maestro, Teresa de Jesús Martínez‐Pérez, Carmen Muñoz Vilafranca, Federico Argüelles, Jesús Legido, Pau Gilabert, Mara Charro, Ana M. Trapero, Hipólito Fernández, Santiago Frago, Luis Hernández Villalba, Esther Muñoz, Eugeni Domènech, on behalf of the ENEIDA registry of GETECCU   +76 more
wiley   +1 more source

Multidisciplinary management of urethral melanoma. [PDF]

Urol Case Rep
Rubia Escribano A, González BG, Feliú AH, Martínez BF, Reboiro AM, Navarro Piñeiro A, De Torres IG, Linares Quevedo AI, De La Morena Gallego JM.   +8 more
europepmc   +1 more source

George Lundberg: La polémica es inherente al campo de la investigación biomédica [PDF]

, 1999
Wingerson, Lois
core  

Integrated Multi‐Omic Analysis Identifies Altered Colonic Brush Border Profile as a Key Feature of Microscopic Colitis

United European Gastroenterology Journal, Volume 14, Issue 1, February 2026.
ABSTRACT Background Microscopic colitis (MC), comprising lymphocytic colitis (LC) and collagenous colitis (CC), is an inflammatory bowel disease with increasing incidence. MC etiopathogenesis remains unknown; however, altered colonic epithelial integrity may underlie uncontrolled luminal antigen passage, triggering immuno‐inflammatory responses ...
Danila Guagnozzi, Ana Maria Gonzalez‐Castro, Yamile Zabana, Fernando Fernández‐Bañares, Andreas Münch, Eva Tristan, Juan‐José Lozano, Julia Sidorova, Beatriz Lobo, Carmen Alonso‐Cotoner, Elba Exposito, Alfredo J. Lucendo, Stefania Landolfi, Ana Benages, Ronald Llerena‐Castro, Maria Dolores Castillo Cejas, Joan Dot, Javier Santos, Maria Vicario   +18 more
wiley   +1 more source

Hepatic CD4 T Cells Predict Hepatocellular Carcinoma Risk on Metabolic Dysfunction‐Associated Steatohepatitis Patients

United European Gastroenterology Journal, Volume 14, Issue 1, February 2026.
ABSTRACT Background & Aims Metabolic dysfunction‐associated steatohepatitis (MASH) increasingly drives hepatocellular carcinoma (HCC) development. We characterized inflammatory infiltrates in liver biopsies from MASH patients who developed HCC versus controls to identify predictive immune signatures. Method Formalin‐fixed paraffin‐embedded (FFPE) liver
Emilse Rodriguez, Peter Simon, Sabrina Dhooge, Marina Fernandez, Patricia Calafat, María Kurpis, Nicolás Nuñez, Jhon Prieto, Anna Saborowski, Arndt Vogel, José Daniel Debes, Domingo Cesar Balderramo, Andre Boonstra, Pablo Alberto Romagnoli   +13 more
wiley   +1 more source

Structured Promoter Variability in Epigenetically Regulated Operons Contributes to Surface Adaptation in Salmonella

Microbial Biotechnology, Volume 19, Issue 2, February 2026.
We discovered that Salmonella uses structured, recurrent variation in epigenetically regulated promoter regions to fine‐tune gene expression, revealing a novel evolutionary strategy for surface adaptation. ABSTRACT Bacterial adaptation to dynamic and hostile environments often relies on the ability to modify surface structures, which are subjected to ...
Rocío Fernández‐Fernández, Gabriel Gutiérrez, Francine Piubeli, Junkal Garmendia, Carmen R. Beuzón, María Antonia Sánchez‐Romero   +5 more
wiley   +1 more source