Results 61 to 70 of about 18,913,418 (345)

Investigation protocol: Acromegaly and its investigation [PDF]

Clinical Endocrinology, 1999
The diagnosis of acromegalyAcromegaly is an uncommon but serious disease due to anexcessive production of growth hormone (GH), usually from apituitary tumour. Although it has an insidious onset, onceclinically suspected its diagnosis is not usually difficult.
Duncan E., Wass J.A.H.
openaire   +6 more sources

Social Functioning Within the First Years After Pediatric Brain Tumor Diagnosis and the Relationship With Family Psychosocial Risk

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Survivors of pediatric brain tumors (PBTs) can experience long‐term social difficulties, impacting quality of life. Beyond medical and environmental factors, family psychosocial risk may play a role in social outcomes by shaping the caregiving environment and may provide intervention options.
Renske H. Houben, Marisa H. Huisman, Martha A. Grootenhuis, Femke K. Aarsen, Marita Partanen   +4 more
wiley   +1 more source

Mogamulizumab versus investigator’s choice of chemotherapy regimen in relapsed/refractory adult T-cell leukemia/lymphoma

Haematologica, 2018
Mogamulizumab, a humanized defucosylated anti-C-C chemokine receptor 4 monoclonal antibody, has been approved in Japan for the treatment of C-C chemokine receptor 4-positive adult T-cell leukemia/lymphoma (ATL). This phase II study evaluated efficacy and
A. Phillips, P. Fields, O. Hermine, J. Ramos, B. Beltrán, J. Pereira, F. Wandroo, T. Feldman, G. Taylor, A. Sawas, J. Humphrey, M. Kurman, J. Moriya, K. Dwyer, M. Leoni, K. Conlon, L. Cook, J. Gonsky, S. Horwitz   +18 more
semanticscholar   +1 more source

Incidence of herpes zoster and postherpetic neuralgia in Italian adults aged ≥50 years: A prospective study

Preventive Medicine Reports, 2019
Herpes zoster (HZ) mainly affects older adults and immunocompromised individuals and is usually characterized by a unilateral painful skin rash. Its most common complication, postherpetic neuralgia (PHN), may cause chronic debilitating pain lasting for ...
Andrea Salvetti, Vincenzo Ferrari, Remigio Garofalo, Pietro Gazzaniga, Alessandro Guerroni, Antonio Metrucci, Aurelio Sessa, Maria Loretta Severi, Giulio Nati, Mauro Ruggeri, Alessandro Rossi, Laura Cappellari, Kusuma Gopala, Roberta Tosatto, Benedetto Simone   +14 more
doaj   +1 more source

Retrospective Analysis of Donor Lymphocyte Infusions in Pediatric Patients With Mixed Chimerism After Hematopoietic Stem Cell Transplantation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Allogeneic hematopoietic stem cell transplantation (alloHSCT) is an essential therapy for several malignant and nonmalignant diseases, but relapse and graft loss remain the principal threats to its success. Routine monitoring of chimerism and minimal residual disease (MRD) enables early detection of imminent recurrence and guides ...
Carmen Junk, Sebastian Michaelis, Michaela Döring, Thomas Eichholz, Ursula Holzer, Martin Ebinger, Tim Flaadt, Rupert Handgretinger, Peter Lang, Jan Frederic Weller, Markus Mezger   +10 more
wiley   +1 more source

Preclinical efficacy studies in investigator brochures: Do they enable risk–benefit assessment?

PLoS Biology, 2018
Human protection policies require favorable risk–benefit judgments prior to launch of clinical trials. For phase I and II trials, evidence for such judgment often stems from preclinical efficacy studies (PCESs). We undertook a systematic investigation of
S. Wieschowski, W. Chin, Carole A. Federico, Sören Sievers, J. Kimmelman, D. Strech   +5 more
semanticscholar   +1 more source

Code Base Investigator v1.2.0

<p>Although a minor release, Code Base Investigator v1.2.0 includes a few significant changes.</p> <blockquote> <p><strong>IMPORTANT</strong><br>In previous releases of Code Base Investigator, the main script was
Douglas Jacobsen, John Pennycook, Jason Sewall   +2 more
core   +1 more source

[EB 2010, Young Investigator]

, 2010
[Title supplied by cataloger]Young Investigator Adrian Salic at Experimental Biology ...
Unknown
core   +4 more sources

THE OBSTRUCTION OF THE ADMINISTRATION OF JUSTICE AND PRELIMINARY INVESTIGATION: PROBLEMS OF THE OBJECT AND THE OBJECTIVE SIDE

Правоприменение, 2018
The subject. The article is devoted to the investigation of the main direct object and the circle of victims are subjected of harm by criminal acts stipulated by pts. 1, 2 of art.
A. V. Boyarskaya
doaj   +1 more source

Clinical trial insurance in Serbia [PDF]

Hospital Pharmacology, 2015
Prior the commencement of the clinical trial in Serbia the Sponsor is obliged to provide the insurance policy covering the patient's bodily injury and damaged health caused by the clinical trial. According to provisions of Serbian Insurance law insurance
Žagar Zlatko A.
doaj   +1 more source