Results 91 to 100 of about 25,018 (225)

STUDI DAMPAK EL NINO DAN INDIAN OCEAN DIPOLE (IOD) TERHADAP CURAH HUJAN DI PANGKALPINANG

, 2013
ABSTRAK El Nino dan Indian Ocean Dipole (IOD) merupakan fenomena global yang memberikan pengaruh terhadap curah hujan yang terjadi di wilayah Indonesia. Besar kecilnya pengaruh itu beragam dari satu tempat ke tempat yang lain. Di kota Pangkalpinang yang
Akmad Fadholi
core   +1 more source

Behandlung von Magen- und Darmleiden mit Iod. (Wratsche, 1896, No. 18, S. 511)

, 1900
BEHANDLUNG VON MAGEN- UND DARMLEIDEN MIT IOD. (WRATSCHE, 1896, NO. 18, S. 511) Le Physiologiste Russe (-) Le Physiologiste Russe (2) (a0005) Behandlung von Magen- und Darmleiden mit Iod. (Wratsche, 1896, No. 18, S.
Kotschoroffski, L.
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sGC stimulator BAY 41‐8543 improves survival and ventricular function in a rat model of doxorubicin‐induced cardiomyopathy with nephrotic syndrome

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Anthracyclines such as doxorubicin (DOXO) remain a cornerstone of cancer therapy but are associated with a high risk of cardiotoxicity and subsequent heart failure (HF). Impairment of NO/soluble guanylyl cyclase (sGC)/cGMP pathway has been reported in anthracycline‐induced cardiomyopathy.
Olga Gawrys, Petra Škaroupková, Soňa Kikerlová, Zdeňka Vaňourková, Martina Hüttl, Olga Lenčová, Kasin Yadunandam Anandam, Svenja Stomberg, Sönke Behrends, Barbara Szeiffová Bačová, Matúš Sykora, Lisa Dietz, Peter Sandner, Luděk Červenka, Martin Štěrba   +14 more
wiley   +1 more source

The interdecadal variation of the relationship between ENSO and the IOD’s eastern and western poles around 2000

Frontiers in Marine Science
The El Niño-Southern Oscillation (ENSO) and Indian Ocean Dipole (IOD) coupling exhibits important globe climate impacts. The relationship of ENSO with the IOD’s eastern pole (EP) and western pole (WP) and its interdecadal variation have not been ...
Xuelun Huang, Xuelun Huang, Li Yan, Li Yan, Jianjun Xu, Jianjun Xu, Shaojun Zheng   +6 more
doaj   +1 more source

Rifaximin ameliorates memory impairment and Alzheimer's pathological changes in APP/PS1 mice associated with changes in the gut microbiome–bile acids–serum metabolites networks

British Journal of Pharmacology, EarlyView.
Background and Purpose Modifying the brain–gut–microbiota axis has emerged as a promising therapeutic strategy against Alzheimer's disease (AD). Whether rifaximin, a non‐absorbed and non‐systemic antibiotic, can be applied to the treatment of AD remains unexplored.
Di Wu, Mei‐Tong Nie, Jixian Lin, Yang Liu, Yong Wang, Min Chu, Lan Zheng, Jing Zhao   +7 more
wiley   +1 more source

Potential Refractive Error Due to Axial Displacement of Intraocular Lenses with Clinically Relevant Compression Diameters

Clinical Ophthalmology
Andrew Maxwell,1,* James S Marotta,2,* Maddi McGough,2,* Neaz Almir,2,* Sandy Valenzuela,2,* Alesha LaFleur,2,* Marcia D Ong,2,* Kamal K Das,2,* Doug Wensrich2,*1InSight Vision Center, California Eye Institute, Fresno, CA, USA; 2Research &amp ...
Maxwell A, Marotta JS, McGough M, Almir N, Valenzuela S, LaFleur A, Ong MD, Das KK, Wensrich D   +8 more
doaj  

NEDD4 Promotes Hepatocellular Carcinoma Progression Through Ubiquitin‐Dependent Degradation of EPHB6

Cancer Science, EarlyView.
NEDD4 drives K48‐linked polyubiquitination and proteasomal degradation of EPHB6, activating TGF‐beta SMAD2/3 signaling and upregulating EMT markers to promote tumor progression. ABSTRACT Neural precursor cell expressed developmentally down‐regulated 4 (NEDD4) has been implicated in the progression of various human malignancies, including hepatocellular
Guowei Zhang, Mengxuan Ji, Zhiyi Liu, Jiawei Xu, Qinghe Hu, Xue Zhang, Jie Qiu, Kai Wu, Bin Zhang, Yi He, Hengliang Shi   +10 more
wiley   +1 more source

PLIN5 Protects Against Ang II‐Induced Podocyte Lipotoxicity by Interacting With FKBP8 and Preserving Lipid Droplet–Mitochondria Contact

Cell Proliferation, EarlyView.
PLIN5‐FKBP8 tethers lipid droplets to mitochondria to counteract Ang II‐induced lipotoxicity. ABSTRACT Chronic kidney disease (CKD) remains a major global health challenge. Angiotensin II (Ang II)‐induced lipotoxicity is an important contributor to podocyte injury.
Ping Wang, Wenjie Chen, Jingjing Ke, Hongtu Hu, Zhuan Peng, Yue Qi, Guohua Ding, Jijia Hu   +7 more
wiley   +1 more source

LGR6 couples maresin 1 signaling to glycolytic flux and protein lactylation for the rescue of diabetic cardiomyopathy

Journal of Diabetes Investigation, EarlyView.
MaR1 activates LGR6‐AMPK signaling to restore metabolic flexibility in diabetic hearts. Glycolytic recovery replenishes intracellular lactate to rescue protective protein lysine lactylation, which reactivates PINK1/Parkin‐mediated mitophagy to eliminate damaged mitochondria.
Bin Feng, Chao Chen, Lin Chen, Yuqiong Chen, Wenjun Mao, Peiran Yu, Hao Yu, Bimin Shi, Nannan Zhang   +8 more
wiley   +1 more source

USP25 promotes ferroptosis in diabetic retinopathy by deubiquitinating p53 and suppressing the GPX4/SLC7A11 axis

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Objective To explore the expression of the deubiquitinase (DUB) USP25 in diabetic retinopathy (DR) and its mechanistic role in regulating ferroptosis. Methods Bioinformatics was used to screen for DR‐related DUB candidate genes. USP25 expression was validated in a streptozotocin‐induced diabetic mouse model and high glucose (HG)‐treated ARPE ...
Yanjun Gao, Wenjing Zhao, Qiannan Chai, Cunxi Ye   +3 more
wiley   +1 more source