Results 91 to 100 of about 31,512 (243)

Rational Design of Broad‐Spectrum Anti‐Enteroviral Molecular Glues Targeting Enteroviral RNAi Suppressors

open access: yesAdvanced Science, EarlyView.
By leveraging this homodimerization mechanism, molecular glues were rationally designed to induce dysfunctional 3A dimerization, thereby restoring antiviral RNAi. The optimal molecular glue, VTP‐32, demonstrated potent and pan‐enterovirus (groups A, B, D) antiviral effects.
Yuan Fang   +13 more
wiley   +1 more source

Decoding the Mechanism of Action of a Parasite TGFβ Antagonist Inspires the Creation of Cell‐Type‐Specific TGFβ Modulators

open access: yesAdvanced Science, EarlyView.
The mammalian TGFβ interacts with ubiquitously expressed TGFBR1 and TGFBR2, and current TGFβ‐targeting agents are non‐cell‐selective. The cooperative interaction of the modular parasite TGFβ antagonist with multiple host (co‐)receptors empowers the design of TGM chimeras and bispecific antibodies that activate or inhibit TGFβ signaling in a cell ...
Maarten van Dinther   +13 more
wiley   +1 more source

Memristive Physical Reservoir Computing

open access: yesAdvanced Science, EarlyView.
Memristors’ nonlinear dynamics and input‐dependent memory effects make them ideal candidates for high‐performance physical reservoir computing (RC). Based on their conductance modulation, memristors can be classified as electronic or optoelectronic types.
Dian Jiao   +9 more
wiley   +1 more source

Natural Resistance to Ovarian Hyperstimulation Syndrome in Estrildid Finches Reveals Macrophage GPR183 as a Potential Therapeutic Target

open access: yesAdvanced Science, EarlyView.
Ovarian macrophage depletion reverses OHSS resistance in estrildid finches and exacerbates OHSS symptoms in rats. Activating macrophage GPR183 alleviates OHSS by reducing pro‐inflammatory factors, increasing immunomodulatory molecules, remodeling CD44/SDC4‐mediated communication, and restoring immune homeostasis.
Xiaofei Yan   +11 more
wiley   +1 more source

Selective Electrolysis of Water Under Artificial Seawater Conditions Using Transition Metal Borate Anodes

open access: yesAdvanced Energy Materials, EarlyView.
The borate‐based cobalt‐iron catalyst promotes selective oxidation of water rather than chlorine evolution reaction during electrolysis of seawater. When integrated into a zero‐gap electrolyzer prototype, this catalyst supports robust splitting of artificial seawater into oxygen and hydrogen on an extended timescale.
Ananta R. Fareza   +10 more
wiley   +1 more source

Multiscale Perspectives on Perovskite Instability: From Atomistic Deformation to Device Degradation in Perovskite Solar Cells

open access: yesAdvanced Energy Materials, EarlyView.
Multiscale perspectives on how excess charges in soft lead halide perovskites induce operational instability in photovoltaic devices are presented. Localized carriers formed under thermodynamic non‐equilibrium states modify atomistic interactions and drive lattice distortions, accelerating device degradation.
Joo‐Hong Lee   +6 more
wiley   +1 more source

Enabling Long Term, Shelf‐Stable Perovskite Solar Cells: Alumina Barriers to Protect Perovskite Devices from Moisture and Oxygen

open access: yesAdvanced Energy Materials, EarlyView.
This study reports a packaging strategy for perovskite photovoltaic devices using atomic layer deposition (ALD) of aluminum oxide. Through optimization of deposition temperature and oxidant chemistry, researchers develop a 50 nm barrier layer with superior water vapor (WVTR) and oxygen transmission rates (OTR).
Melissa A. Davis   +11 more
wiley   +1 more source

Health Consequences of Iodine Deficiency

open access: yesSultan Qaboos University Medical Journal, 2007
Iodine Deficiency Disorders (IDD) are one of the biggest worldwide public health problem of today. Their effect is hidden and profoundly affects the quality of human life.
Umesh Kapil
doaj  

High‐Sublimation‐Temperature Additives for Efficient Perovskite Solar Cells via Single‐Source Evaporation

open access: yesAdvanced Energy Materials, EarlyView.
The introduction of high‐sublimation‐temperature additives during the mechanosynthesis of FAPbI3 powders enables the single‐source evaporation of phase‐pure, additive‐free FAPbI3 thin films of high optoelectronic quality. The additive‐engineered deposition process yields photovoltaic devices with stabilized efficiencies exceeding 18% for an active ...
Zongbao Zhang   +13 more
wiley   +1 more source

Collaboration to optimize dietary intakes of salt and iodine: a critical but overlooked public health issue

open access: yesBulletin of the World Health Organization
Norm Campbell   +5 more
doaj   +1 more source

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