Results 51 to 60 of about 536,774 (369)

A competitive binding-mass spectrometry strategy for high-throughput evaluation of potential critical quality attributes of therapeutic monoclonal antibodies

mAbs, 2022
Therapeutic monoclonal antibodies (mAbs) have a propensity to host a large number of chemical and enzymatical modifications that need to be properly assessed for their potential impact on target binding.
Zhengqi Zhang, Yuetian Yan, Shunhai Wang, Ning Li   +3 more
doaj   +1 more source

Spin projection chromatography [PDF]

, 2003
We formulate the many-body spin dynamics at high temperature within the non-equilibrium Keldysh formalism. For the simplest XY interaction, analytical expressions in terms of the one particle solutions are obtained for linear and ring configurations. For small rings of even spin number, the group velocities of excitations depend on the parity of the ...
arxiv   +1 more source

ADVANCING THE SEPARATION SCIENCES THROUGH THE DELIVERY OF NEW MATERIALS, TECHNOLOGY AND METHODOLOGY. [PDF]

, 2013
A thesis and collection of works submitted to Plymouth University in partial fulfilment for the degree of DOCTOR OF ...
Paull, Brett
core   +2 more sources

Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation

FEBS Letters, EarlyView.
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt, Marcus S. Münchhoff, Jacqueline Krohn, Philip M. Palarz, Manuel H. Taft, Johannes N. Greve, Nataliya Di Donato, Falk F. R. Buettner, Dietmar J. Manstein   +8 more
wiley   +1 more source

BARCHAN: Blob Alignment for Robust CHromatographic ANalysis [PDF]

Journal of Chromatography A, Volume 1484, February 2017, Pages 65-72, 2017
Comprehensive Two dimensional gas chromatography (GCxGC) plays a central role into the elucidation of complex samples. The automation of the identification of peak areas is of prime interest to obtain a fast and repeatable analysis of chromatograms.
arxiv   +1 more source

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

Molecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park, Jae Won Oh, Hyewon Chung, Jung Won Kwon, Yi Rang Na, Kwang Pyo Kim, Seung Hyeok Seok   +6 more
wiley   +1 more source

Extraction and Purification of Lactoferrin from Camel Milk and Investigation of Its Amylase Activity

Journal of Mazandaran University of Medical Sciences, 2022
Background and purpose: Lactoferrin is found in mucus, milk, and colostrum secretions and has antimicrobial activities, improves iron absorption, and enhances immune responses. Lactoferrin has the ability to degrade starch.
Saeed Zibaei, Anis Bakhshani, Ali Bidmeshkipour   +2 more
doaj  

Weak anion-exchange hypercrosslinked sorbent in on-line solid-phase extraction-liquid chromatography coupling to achieve automated determination with an effective clean-up [PDF]

, 2010
A mixed-mode polymeric sorbent was on-line coupled to liquid chromatography (LC) for the first time and applied it to the selective solid-phase extract a group of pharmaceuticals in complex environmental water samples. The mixed-mode polymeric sorbent is
Borrull, F., Cormack, P.A.G., Fontanals, N., Marce, R.M., Sherrington, D.C.   +4 more
core   +1 more source

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

Silica gel functionalized with imidazolium group via click chemistry – new stationary phase for ion chromatography

Chimica Techno Acta, 2021
This manuscript describes the preparation of a simple effective ion-exchange material based on silica gel, on the surface of which methylimidazolium bromide is fixed using a click reaction.
D. A. Chuprynina, I. A. Lupanova, V. V. Konshin, D. N. Konshina   +3 more
doaj   +1 more source