Results 41 to 50 of about 948,699 (249)

The proposed channel-enzyme transient receptor potential melastatin 2 does not possess ADP ribose hydrolase activity

eLife, 2016
Transient Receptor Potential Melastatin 2 (TRPM2) is a Ca2+-permeable cation channel essential for immunocyte activation, insulin secretion, and postischemic cell death.
Iordan Iordanov, Csaba Mihályi, Balázs Tóth, László Csanády   +3 more
doaj   +1 more source

Preventive treatment with ginsenoside Rb1 ameliorates monocrotaline-induced pulmonary arterial hypertension in rats and involves store-operated calcium entry inhibition

Pharmaceutical Biology, 2020
Context Ginsenoside Rb1, the main active ingredient of ginseng, exhibits ex vivo depression of store-operated calcium entry (SOCE) and related vasoconstriction in pulmonary arteries derived from pulmonary hypertension (PH) rats.
Rui-Xing Wang, Rui-Lan He, Hai-Xia Jiao, Run-Tian Zhang, Jing-Yi Guo, Xiao-Ru Liu, Long-Xin Gui, Mo-Jun Lin, Zhi-Juan Wu   +8 more
doaj   +1 more source

Ion channels [PDF]

BMJ, 1997
Ion channels are protein pores in the cell membrane that allow the passage of ions down their respective electrochemical gradients.1 The ubiquitous presence of ion channels among cells of unicellular and multicellular organisms suggests their importance in maintaining cellular integrity. Our understanding of the part that they play in disease has grown
Paul D. Abel, El-Nasir Lalani, Marc Laniado   +2 more
openaire   +3 more sources

Monod-Wyman-Changeux Analysis of Ligand-Gated Ion Channel Mutants [PDF]

, 2017
We present a framework for computing the gating properties of ligand-gated ion channel mutants using the Monod-Wyman-Changeux (MWC) model of allostery. We derive simple analytic formulas for key functional properties such as the leakiness, dynamic range,
Einav, Tal, Phillips, Rob
core   +4 more sources

Enzyme activity and selectivity filter stability of ancient TRPM2 channels were simultaneously lost in early vertebrates

eLife, 2019
Transient Receptor Potential Melastatin 2 (TRPM2) is a cation channel important for the immune response, insulin secretion, and body temperature regulation. It is activated by cytosolic ADP ribose (ADPR) and contains a nudix-type motif 9 (NUDT9)-homology
Iordan Iordanov, Balázs Tóth, Andras Szollosi, László Csanády   +3 more
doaj   +1 more source

The Citrus Flavonoid Hesperetin Has an Inadequate Anti-Arrhythmic Profile in the ΔKPQ Na_V1.5 Mutant of the Long QT Type 3 Syndrome

Biomolecules, 2020
Type 3 long QT syndromes (LQT3) are associated with arrhythmogenic gain-of-function mutations in the cardiac voltage-gated Na+ channel (hNaV1.5). The citrus flavanone hesperetin (HSP) was previously suggested as a template molecule to develop new anti ...
Julio Alvarez-Collazo, Alejandro López-Requena, Julio L. Alvarez, Karel Talavera   +3 more
doaj   +1 more source

PPI-MASS: An Interactive Web Server to Identify Protein-Protein Interactions From Mass Spectrometry-Based Proteomics Data

Frontiers in Molecular Biosciences, 2021
Mass spectrometry-based proteomics methods are widely used to identify and quantify protein complexes involved in diverse biological processes. Specifically, tandem mass spectrometry methods represent an accurate and sensitive strategy for identifying ...
Mariela González-Avendaño, Mariela González-Avendaño, Simón Zúñiga-Almonacid, Simón Zúñiga-Almonacid, Simón Zúñiga-Almonacid, Ian Silva, Ian Silva, Boris Lavanderos, Boris Lavanderos, Felipe Robinson, Felipe Robinson, Roberto Rosales-Rojas, Roberto Rosales-Rojas, Fabio Durán-Verdugo, Wendy González, Wendy González, Mónica Cáceres, Mónica Cáceres, Oscar Cerda, Oscar Cerda, Ariela Vergara-Jaque, Ariela Vergara-Jaque   +21 more
doaj   +1 more source

Voltage dependence of Hodgkin-Huxley rate functions for a multi-stage K channel voltage sensor within a membrane [PDF]

, 2014
The activation of a $K^+$ channel sensor in two sequential stages during a voltage clamp may be described as the translocation of a Brownian particle in an energy landscape with two large barriers between states.
Vaccaro, Samuel R.
core   +2 more sources

Lipid-Centric Approaches in Combating Infectious Diseases: Antibacterials, Antifungals and Antivirals with Lipid-Associated Mechanisms of Action

Antibiotics, 2023
One of the global challenges of the 21st century is the increase in mortality from infectious diseases against the backdrop of the spread of antibiotic-resistant pathogenic microorganisms.
Olga S. Ostroumova, Svetlana S. Efimova
doaj   +1 more source

Human sperm ion channel (dys)function:implications for fertilization [PDF]

, 2019
BACKGROUND: Intensive research on sperm ion channels has identified members of several ion channel families in both mouse and human sperm. Gene knock-out studies have unequivocally demonstrated the importance of the calcium and potassium conductances in ...
Barratt, Christopher L. R., Brown, Sean G., Martins da Silva, Sarah J., Publicover, Stephen J.   +3 more
core   +4 more sources