Results 51 to 60 of about 948,699 (249)
Obligate coupling of CFTR pore opening to tight nucleotide-binding domain dimerization
eLife, 2016 In CFTR, the chloride channel mutated in cystic fibrosis (CF) patients, ATP-binding-induced dimerization of two cytosolic nucleotide binding domains (NBDs) opens the pore, and dimer disruption following ATP hydrolysis closes it.
Csaba Mihályi +2 more
doaj +1 more source
Cell-specific mechanisms of TMEM16A Ca2+-activated chloride channel in cancer
Molecular Cancer, 2017 TMEM16A (known as anoctamin 1) Ca2+-activated chloride channel is overexpressed in many tumors. TMEM16A overexpression can be caused by gene amplification in many tumors harboring 11q13 amplification.
Hui Wang +6 more
doaj +1 more source
New Challenges Resulting From the Loss of Function of Nav1.4 in Neuromuscular Diseases
Frontiers in Pharmacology, 2021 The voltage-gated sodium channel Nav1.4 is a major actor in the excitability of skeletal myofibers, driving the muscle force in response to nerve stimulation.
Sophie Nicole +3 more
doaj +1 more source
, 1990 A relativistic electron beam propagating through a plasma in the ion-focused regime exhibits an electromagnetic instability at a resonant frequency {omega} {approximately} 2{gamma}{sup 2} {omega}{sub {beta}}. Growth is enhanced by optical guiding in the ion channel, which acts as dielectric waveguide, with fiber parameter V {approximately} 2 (I/I{sub A}
Whittum, D H, Sessler, A M, Dawson, J M
openaire +5 more sources
Channel Optical Waveguides and Directional Couplers in GaAs -- Imbedded and Ridged [PDF]
, 1973 Two-channel imbedded directional couplers were fabricated with proton implantation, yielding complete light transfer in 2 mm. Ridged channel guides were fabricated by ion-micromachining epitaxial layers, and a method of directional coupling was ...
Garmire, E. +4 more
core +2 more sources
Mitochondrial Ion Channels [PDF]
Annual Review of Physiology, 2007 In work spanning more than a century, mitochondria have been recognized for their multifunctional roles in metabolism, energy transduction, ion transport, inheritance, signaling, and cell death. Foremost among these tasks is the continuous production of ATP through oxidative phosphorylation, which requires a large electrochemical driving force for ...
openaire +3 more sources
The conduction pathway of potassium channels is water free under physiological conditions. [PDF]
, 2019 Ion conduction through potassium channels is a fundamental process of life. On the basis of crystallographic data, it was originally proposed that potassium ions and water molecules are transported through the selectivity filter in an alternating ...
Chevelkov, V. +9 more
core +1 more source
Scientific Reports, 2018 Bacterial lipopolysaccharides (LPS) activate the TRPA1 cation channels in sensory neurons, leading to acute pain and inflammation in mice and to aversive behaviors in fruit flies.
Justyna B. Startek +3 more
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Ion channels and ion selectivity [PDF]
Essays in Biochemistry, 2017 Specific macromolecular transport systems, ion channels and pumps, provide the pathways to facilitate and control the passage of ions across the lipid membrane. Ion channels provide energetically favourable passage for ions to diffuse rapidly and passively according to their electrochemical potential.
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FGF14 modulates resurgent sodium current in mouse cerebellar Purkinje neurons
eLife, 2014 Rapid firing of cerebellar Purkinje neurons is facilitated in part by a voltage-gated Na+ (NaV) ‘resurgent’ current, which allows renewed Na+ influx during membrane repolarization.
Haidun Yan +3 more
doaj +1 more source