Results 51 to 60 of about 942,347 (195)

The conduction pathway of potassium channels is water free under physiological conditions. [PDF]

, 2019
Ion conduction through potassium channels is a fundamental process of life. On the basis of crystallographic data, it was originally proposed that potassium ions and water molecules are transported through the selectivity filter in an alternating ...
Chevelkov, V., de Groot, B., Hendriks, K., Kopec, W., Lange, A., Lange, S., Michl, D., Shi, C., Sun, H., Öster, C.   +9 more
core   +1 more source

High-Resolution Proteomics Unravel a Native Functional Complex of Cav1.3, SK3, and Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels in Midbrain Dopaminergic Neurons

Cells
Pacemaking activity in substantia nigra dopaminergic neurons is generated by the coordinated activity of a variety of distinct somatodendritic voltage- and calcium-gated ion channels. We investigated whether these functional interactions could arise from
Maya Belghazi, Cécile Iborra, Ophélie Toutendji, Manon Lasserre, Dominique Debanne, Jean-Marc Goaillard, Béatrice Marquèze-Pouey   +6 more
doaj   +1 more source

FGF14 modulates resurgent sodium current in mouse cerebellar Purkinje neurons

eLife, 2014
Rapid firing of cerebellar Purkinje neurons is facilitated in part by a voltage-gated Na+ (NaV) ‘resurgent’ current, which allows renewed Na+ influx during membrane repolarization.
Haidun Yan, Juan L Pablo, Chaojian Wang, Geoffrey S Pitt   +3 more
doaj   +1 more source

Cyclodextrin ion channels

Org. Biomol. Chem., 2014
Cyclodextrin ion channels, assembled by click chemistry, exhibit mechanistically diverse behaviors including transient blockage by hydrophobic guests.
Jonathan K W, Chui, T M, Fyles
openaire   +3 more sources

Fractional diffusion modeling of ion channel gating [PDF]

, 2004
An anomalous diffusion model for ion channel gating is put forward. This scheme is able to describe non-exponential, power-law like distributions of residence time intervals in several types of ion channels.
A. L. Hodgkin, A. Toib, B. D. Hughes, B. Hille, D. R. Cox, G. Doetsch, G. H. Weiss, G. H. Weiss, Igor Goychuk, M. A. Lavrentiev, M. F. Shlesinger, N. G. van Kampen, N. W. Goel, Peter Hänggi, R. Gorenflo, R. L. Stratonovich   +15 more
core   +1 more source

Steviol glycosides enhance pancreatic beta-cell function and taste sensation by potentiation of TRPM5 channel activity

Nature Communications, 2017
Steviol glycosides are sweet-tasting compounds isolated from a South American shrub and are increasingly used as sweeteners in foods and beverages. Philippaertet al. demonstrate that steviol glycosides potentiate Ca2+-dependent TRPM5 activity and promote
Koenraad Philippaert, Andy Pironet, Margot Mesuere, William Sones, Laura Vermeiren, Sara Kerselaers, Sílvia Pinto, Andrei Segal, Nancy Antoine, Conny Gysemans, Jos Laureys, Katleen Lemaire, Patrick Gilon, Eva Cuypers, Jan Tytgat, Chantal Mathieu, Frans Schuit, Patrik Rorsman, Karel Talavera, Thomas Voets, Rudi Vennekens   +20 more
doaj   +1 more source

Modulation of the Dipole Potential of Model Lipid Membranes with Phytochemicals: Molecular Mechanisms, Structure–Activity Relationships, and Implications in Reconstituted Ion Channels

Membranes, 2023
Phytochemicals, such as flavonoids, stilbenoids, alkaloids, terpenoids, and related compounds, have a wide range of useful pharmacological properties which cannot be ascribed to binding to a single peptide or protein target alone.
Svetlana S. Efimova, Olga S. Ostroumova
doaj   +1 more source

Episodic neurologic disorders: syndromes, genes, and mechanisms. [PDF]

, 2013
Many neurologic diseases cause discrete episodic impairment in contrast with progressive deterioration. The symptoms of these episodic disorders exhibit striking variety.
Fu, Ying-Hui, Ptáček, Louis J, Russell, Jonathan F   +2 more
core   +2 more sources

Ion Channels☆

British Journal of Pharmacology, 2004
Guide to Receptors and ChannelsSPH Alexander, A Mathie, JA PetersBritish Journal of Pharmacology (2004) 141, S71–S91.
openaire   +3 more sources

Analysis of the effect of the scorpion toxin AaH-II on action potential generation in the axon initial segment

Scientific Reports
The toxin AaH-II, from the scorpion Androctonus australis Hector venom, is a 64 amino acid peptide that targets voltage-gated Na+ channels (VGNCs) and slows their inactivation. While at macroscopic cellular level AaH-II prolongs the action potential (AP),
Fatima Abbas, Laila Ananda Blömer, Hugo Millet, Jérôme Montnach, Michel De Waard, Marco Canepari   +5 more
doaj   +1 more source