Results 11 to 20 of about 2,338,712 (299)
Hysteretic Conductance in Ion Channel Gating [PDF]
EntropyHysteresis seems to play a critical role in the generation and modulation of electrical signal events in neurons, muscles, and other excitable tissues. In voltage-gated ion channels, hysteretic conductance manifests under cycling changes in transmembrane
Bartek Lisowski +3 more
doaj +3 more sources
Interplay between Gating and Block of Ligand-Gated Ion Channels
Brain Sciences, 2020 Drugs that inhibit ion channel function by binding in the channel and preventing current flow, known as channel blockers, can be used as powerful tools for analysis of channel properties.
Matthew B. Phillips +2 more
doaj +3 more sources
Voltage-dependent gating in a "voltage sensor-less" ion channel.
PLoS Biology, 2010 The voltage sensitivity of voltage-gated cation channels is primarily attributed to conformational changes of a four transmembrane segment voltage-sensing domain, conserved across many levels of biological complexity.
Harley T Kurata +4 more
doaj +2 more sources
Unmasking coupling between channel gating and ion permeation in the muscle nicotinic receptor
eLife, 2021 Whether ion channel gating is independent of ion permeation has been an enduring, unresolved question. Here, applying single channel recording to the archetypal muscle nicotinic receptor, we unmask coupling between channel gating and ion permeation by ...
John R Strikwerda, Steven M Sine
doaj +1 more source
The gates of ion channels and enzymes [PDF]
Trends in Biochemical Sciences, 2010 Protein dynamics are essential for virtually all protein functions, certainly for gating mechanisms of ion channels and regulation of enzyme catalysis. Ion channels usually feature a gate in the channel pore that prevents ion permeation in the closed state.
unknown ( host institution ) +1 more
openaire +3 more sources
Voltage-Gated Ion Channels [PDF]
IEEE Transactions on Nanobioscience, 2005 Voltage-dependent ion channels are membrane proteins that conduct ions at high rates regulated by the voltage across the membrane. They play a fundamental role in the generation and propagation of the nerve impulse and in cell homeostasis. The voltage sensor is a region of the protein bearing charged amino acids that relocate upon changes in the ...
Sands, Z, Grottesi, A, Sansom, MS
openaire +4 more sources
Nature Communications, 2022 Visualizing conformational changes during ion channel gating is crucial to understand their regulation. Here, Gao et al. capture multiple gating intermediates in a CNG channel as well as subtle, lateral voltage sensor movements necessary for channel ...
Xiaolong Gao +6 more
doaj +1 more source
Central cavity dehydration as a gating mechanism of potassium channels
Nature Communications, 2023 The hydrophobic gating model, in which ion permeation is inhibited by the hydrophobicity, rather than a physical occlusion of the nanopore, functions in various ion channels including potassium channels.
Ruo-Xu Gu, Bert L. de Groot
doaj +1 more source
Artificial modulation of the gating behavior of a K+ channel in a KvAP-DNA chimera. [PDF]
PLoS ONE, 2011 We present experiments where the gating behavior of a voltage-gated ion channel is modulated by artificial ligand binding. We construct a channel-DNA chimera with the KvAP potassium channel reconstituted in an artificial membrane.
Andrew Wang, Giovanni Zocchi
doaj +1 more source
Ion channels gated by heat [PDF]
Proceedings of the National Academy of Sciences, 1999 All animals need to sense temperature to avoid hostile environments and to regulate their internal homeostasis. A particularly obvious example is that animals need to avoid damagingly hot stimuli. The mechanisms by which temperature is sensed have until recently been mysterious, but in the last couple of years, we have begun to understand how ...
Cesare P. +3 more
openaire +2 more sources