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Are Ions Involved in the Gating of Calcium Channels?
Science, 1982The rates of activation and deactivation of the currents carried by calcium, strontium, or barium ions through the voltage-sensitive calcium channel of Paramecium are different. The differences cannot be attributed to complications due to internal ion concentration, calcium channel inactivation, potassium current ...
Y, Saimi, C, Kung
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Molecular mechanisms of gated ion channels
Bioelectrochemistry and Bioenergetics, 1986Abstract Ion channels form the basis for intercellular communication in biological systems. With the advent of cloning techniques, it is now possible to sequence the proteins that form such channels. The acetylcholine receptor, for example, which consists of five subunits, and the voltage gated sodium channel have been completely sequenced by Noda et
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The voltage sensor and the gate in ion channels
2003Publisher Summary This chapter illustrates two aspects of ion channels: the gating process and the transduction from the initiating stimulus to the operation of the gate. The gating process is the operation of the gate proper while the transducer may be considered the sensor of the stimulus that ultimately opens and closes the channel.
Francisco, Bezanilla, Eduardo, Perozo
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Voltage Gated Ion Channels and Sleep
The Journal of Membrane BiologyIon channels are integral components of the nervous system, playing a pivotal role in shaping membrane potential, neuronal excitability, synaptic transmission and plasticity. Dysfunction in these channels, such as improper expression or localization, can lead to irregular neuronal excitability and synaptic communication, which may manifest as various ...
Yan, Zhang +5 more
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Opening Ion Channels: Enzyme at the Gate
ChemMedChem, 2007Jun, Chen, Murali, Gopalakrishnan
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Electrostatics of ligand-gated ion channels
Biochemical Society Transactions, 1998C, Adcock, G R, Smith, M S, Sansom
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