Results 61 to 70 of about 43,079 (261)

Optical control of an ion channel gate [PDF]

Proceedings of the National Academy of Sciences, 2013
Significance Engineered light-sensitive ion channels offer the opportunity to govern electrical activity of neurons. To date, developed strategies have relied on specific actions on either ligand-binding or permeation pathways. Here we developed a unique and versatile method, in which the gating machinery of an ATP-activated channel ...
Lemoine, Damien, Habermacher, Chloé, Martz, Adeline, Méry, Pierre-François, Bouquier, Nathalie, Diverchy, Fanny, Taly, Antoine, Rassendren, François, Specht, Alexandre, Grutter, Thomas   +9 more
openaire   +2 more sources

Indolo‐Fused MR‐TADF Materials and their Application in Organelle‐Targeted Bioimaging

Advanced Functional Materials, EarlyView.
Using indolo‐fusion and sulfur bridging, four multi‐resonance thermally activated delayed fluorescent (MR‐TADF) materials are reported based on the quinolino[3,2,1‐de]acridine‐5,9‐dione (QAO) framework. Functionalization of these dyes with phosphonium groups enables cellular imaging with mitochondrial targeting in glassy organic nanoparticles ...
Sushil Sharma, Xujun Qiu, Thomas Kalab, Athan T. Gogoulis, Brian O. Patrick, Zachary M. Hudson   +5 more
wiley   +1 more source

Stochastic models of ion channel gating

Scholarpedia, 2008
Stochastic models of ion channel gating date back as far as the pioneering work of Hodgkin and Huxley (1952), whose gating variables are often interpreted as probabilities. Sakmann and Neher directed the efforts that led to the first single-channel recordings, for which they won the Nobel Prize in Physiology and Medicine in 1991.
Tilman Kispersky, John A. White
openaire   +1 more source

A Bioinspired Sensory‐CAPode With Dual Functionality: Logic Gate and Real‐Time Biosensing

Advanced Functional Materials, EarlyView.
An electrochemical capacitor diode (CAPode) redefines the frontier of iontronics by seamlessly unifying logic computing and biosensing within a single biocompatible platform. Inspired by nature's own ion‐channel circuitry, this elegant ionic system transforms complex chemical signals into precise electrical responses, paving the way for next‐generation
Hanfeng Zhou, Tianle Zheng, Haolin Jin, Xiongjun Zhou, Jiang Qu, Bilal Riaz, Ahmed Bahrawy, Jiajie Chen, Przemyslaw Galek, Julia Grothe, Stefan Kaskel   +10 more
wiley   +1 more source

Performance Enhancement of Tin Chloride‐Incorporated Ferroelectric Polymer‐Based Artificial Synapse for Hardware Neural Networks

Advanced Functional Materials, EarlyView.
This paper proposes a highly efficient ferroelectric artificial synapse device based on an oxide semiconductor and SnCl2‐inserted P(VDF‐TrFE) gate dielectric layer. This FeFET significantly improved the synaptic performance due to the ion‐dipole interaction.
Hyun‐Soo Kim, Hyunkyu Lee, Yeonho Choi, Won Young Jang, Hyungmin Kim, Krishna Moorthy Ponnusamy, Hongseung Lee, Jaewook Yoo, Ji Ye Lee, S. Chandramohan, Seongin Hong, Hagyoul Bae, Hyeon‐Sik Jang, Sang Yeol Lee, Keun Heo   +14 more
wiley   +1 more source

The voltage-sensing domain of kv7.2 channels as a molecular target for epilepsy-causing mutations and anticonvulsants

Frontiers in Pharmacology, 2011
Understanding the molecular mechanisms underlying voltage-dependent gating in voltage-gated ion channels (VGICs) has been a major effort over the last decades. In recent years, changes in the gating process have emerged as common denominators for several
Francesco eMiceli, MariaVirginia eSoldovieri, Fabio Arturo Iannotti, Vincenzo eBarrese, Paolo eAmbrosino, Maria eMartire, Maria Roberta Cilio, Maurizio eTaglialatela, Maurizio eTaglialatela   +8 more
doaj   +1 more source

Magnesium‐Based Transient Bioelectronics, Bio‐Optics and Bio‐Scaffolds

Advanced Functional Materials, EarlyView.
This paper reviews the state of the art and recent advances in magnesium‐based thin‐film, foils, and scaffolds for applications in transient bio‐optics, bioelectronics and tissue engineering. The design principles, fabrication methods, material properties, and integration strategies are discussed in detail.
Massimo Mariello, Yves Leterrier
wiley   +1 more source

Lipid-mediated hydrophobic gating in the BK potassium channel

Nature Communications
Structures of the large-conductance, calcium-activated potassium (BK) channel in the Ca2+ −bound and Ca2+ −free states have suggested that K+ conduction is not gated via a steric closure of the pore-lining helices of the channel, in contrast to the ...
Lucia Coronel, Giovanni Di Muccio, Brad S. Rothberg, Alberto Giacomello, Vincenzo Carnevale   +4 more
doaj   +1 more source

Structure-based membrane dome mechanism for Piezo mechanosensitivity

eLife, 2017
Mechanosensitive ion channels convert external mechanical stimuli into electrochemical signals for critical processes including touch sensation, balance, and cardiovascular regulation. The best understood mechanosensitive channel, MscL, opens a wide pore,
Yusong R Guo, Roderick MacKinnon
doaj   +1 more source

Electrostatically‐Stabilized PEG‐Free Lipid Nanoparticles for Systemic Nucleic Acid Delivery

Advanced Functional Materials, EarlyView.
This work describes non‐PEGylated layered lipid nanoparticles (nonPEG LLNPs), a gene delivery platform that improves upon standard PEGylated LNPs via electrostatic adsorption of charged polymers. nonPEG LLNPs maintain colloidal stability under biological stresses, enhance circulation time, and mitigate accelerated blood clearance and hepatic ...
Namita Nabar, Deeksha Kumaresh, Eduardo Nombera Bueno, Mae Pryor, Paula T. Hammond   +4 more
wiley   +1 more source