Results 91 to 100 of about 43,122 (263)

The Hydrophobic Effect Contributes to the Closed State of a Simplified Ion Channel through a Conserved Hydrophobic Patch at the Pore-Helix Crossing.

Frontiers in Pharmacology, 2015
Ion selectivity-filter structures are strikingly similar throughout the large family of K+ channels and other p-loop-like receptors (i.e., glutamate receptors). At the same time, the triggers for opening these channels, or gating, are diverse.
Michael eYonkunas, Maria eKurnikova
doaj   +1 more source

Light‐Induced Field‐Tunneling Synapses in Solution‐Processed Van Der Waals Heterostructures for Scalable, Retina‐Inspired Optical Sensing

Advanced Functional Materials, EarlyView.
A scalable, solution‐processed WSe2/ZrO2‐x van der Waals heterostructure realizes a light‐induced field‐tunneling synapse (LIFTS) that activates exclusively under bright illumination, emulating the photopic adaptation of the human retina at the device level.
Kijeong Nam, Jihyun Kim, Soobeen Ji, In Soo Kim, Sejin Kim, Eungseon Yeon, Do Kyung Hwang, Iva Plutnarová, Zdeněk Sofer, Sang Min Won, Joohoon Kang   +10 more
wiley   +1 more source

The RyR1 P3528S Substitution Alters Mouse Skeletal Muscle Contractile Properties and RyR1 Ion Channel Gating. [PDF]

Int J Mol Sci, 2023
Thekkedam CG, Dutka TL, Van der Poel C, Burgio G, Dulhunty AF.   +4 more
europepmc   +1 more source

Memristive‐Gated RC‐Delay Synaptic Transistors for Time‐Encoded Analog in‐Memory Computing

Advanced Functional Materials, EarlyView.
A Memristive‐Gated Transistor for Time‐Encoded Analog In‐Memory Computing — By exploiting the RC delay of a self‐rectifying interface‐type memristor, nonlinear I–V distortion is structurally bypassed, enabling 3‐bit nonvolatile memory, spike‐timing‐based analog encoding, and hardware‐calibrated reservoir‐computing validation within a unified device ...
Yun‐Seo Shin, Eunjoo Yoo, Ki‐Hoon Son, Hyun‐Sik Kim, Dae‐Hee Han, Jeong Hyeon Son, Seung Hwan Lee, Hong‐Sub Lee   +7 more
wiley   +1 more source

Molecular architecture of the fungal-specific potassium channel TOK1

Nature Communications
In Candida albicans, potassium (K+) channels fine-tune ionic balance under stress, contributing to host colonization. Fungal two-pore domain, outwardly rectifying potassium (TOK) channels remain insufficiently characterized despite evidence implicating ...
Brice Durocher, Rían W. Manville, Rui Yan, Zhiheng Yu, Geoffrey W. Abbott, Alexandria N. Miller   +5 more
doaj   +1 more source

Phase-sensitive detection of anomalous diffusion dynamics in the neuronal membrane induced by ion channel gating. [PDF]

Phys Med Biol, 2023
Choi H, Iyer RR, Renteria CA, Boppart SA.   +3 more
europepmc   +1 more source

Cellular Responses to Mechanical Cues Across Scales: From Fundamental Insights to Translational Potential

Advanced Healthcare Materials, EarlyView.
This review examines how cellular behavior is regulated by mechanical cues transmitted through soft biomaterials, from single‐cell mechanosensing to tissue‐level adaptation. It highlights why physiological relevance, rather than model complexity alone, is critical for translational mechanobiology and introduces a scoring framework linking material ...
Mathias Polz, Manuel P. Kainz, Niklas Haider, Theresa Rienmüller, Kerstin Lenk, Rupert Kargl, Michele Terzano, Gerhard Sommer, Gerhard A. Holzapfel, Julia Fuchs   +9 more
wiley   +1 more source

2D-dwell-time analysis with simulations of ion-channel gating using high-performance computing. [PDF]

Biophys J, 2023
Oikonomou E, Gruber T, Chandra AR, Höller S, Alzheimer C, Wellein G, Huth T.   +6 more
europepmc   +1 more source

Cooperative gating between ion channels

General physiology and biophysics, 2014
Cooperative gating between ion channels, i.e. the gating of one channel directly coupled to the gating of neighboring channels, has been observed in diverse channel types at the single-channel level. Positively coupled gating could enhance channel-mediated signaling while negative coupling may effectively reduce channel gating noise.
openaire   +3 more sources

Ion-Channel Gating: Twist to open [PDF]

Current Biology, 1995
Three-dimensional images of the open state of the nicotinic acetylcholine receptor have been obtained at 9 A resolution. Comparison with the closed state reveals the structural basis of channel gating.
openaire   +2 more sources