Results 221 to 230 of about 43,075 (262)
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A Light-Gated Synthetic Ion Channel
Organic Letters, 2008A gated synthetic ion channel with beta-cyclodextrin as the pore and azobenzene as the gate is reported. Irradiation converts a tethered trans-azobenzene to cis-azobenzene which likely transforms the channel from a self-inclusion complex to a dissociated structure.
Parag V, Jog, Mary S, Gin
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Ion Channels: Opening the Gate
Science, 1996A recent paper in Science ( 12 Jan., p. 213 ) and two papers in Neuron (H. P. Larsson et al. , in press, and N. Yang et al. , vol. 16, p. 113) demonstrate that a charged portion of the sodium and potassium ion channel (S4)
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On the opening of voltage-gated ion channels
Physiology & Behavior, 2007Voltage-gated ion channels are key players in fast neuronal signalling. Detailed knowledge about channel gating is essential for our understanding of channel function in general and of drug action of channels in particular. Despite a number of recent atomic channel structures, the opening of voltage-gated channels is the subject of heated debates. Here
Fredrik, Elinder +2 more
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A model of the gating of ion channels
Biochimica et Biophysica Acta (BBA) - Biomembranes, 1988The gating of ion channels in biological membranes has usually been described in terms of Markov transitions between a few discrete open or closed states. Such models predict that the distributions of open and closed durations decay as a sum of exponential terms.
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Cyclic Nucleotide-Gated Ion Channels
Annual Review of Cell and Developmental Biology, 2003▪ Abstract  Cyclic nucleotide-gated (CNG) ion channels were first discovered in rod photoreceptors, where they are responsible for the primary electrical signal of the photoreceptor in response to light. CNG channels are highly specialized membrane proteins that open an ion-permeable pore across the membrane in response to the direct binding of ...
Kimberly, Matulef, William N, Zagotta
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2008
How and where simple volatile organic molecules act in the central nervous system to cause loss of consciousness and insensitivity to pain has eluded investigation; yet remarkable progress has been made recently towards identifying possible molecular targets through which the mechanism of anesthesia is tranduced.
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How and where simple volatile organic molecules act in the central nervous system to cause loss of consciousness and insensitivity to pain has eluded investigation; yet remarkable progress has been made recently towards identifying possible molecular targets through which the mechanism of anesthesia is tranduced.
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The kinetics of voltage-gated ion channels
Quarterly Reviews of Biophysics, 1994When Hodgkin & Huxley (1952) first embarked on the analysis of their voltageclamp data on the ionic currents in the squid giant axon, they hoped to be able to deduce a mechanism from it, but it soon became clear that the electrical data would by themselves yield only very general information about the class of system likely to be involved.
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K+ Channels Gated by Voltage and Ions
Annual Review of Physiology, 1984Several different potassium channels are present in membranes of nerve, muscle, and other types of cells (50, 59, 75, 79). These channels come in all sorts of sizes and shapes. K+ channels range from the tiny (2 pS) delayed rectifier of Helix neuron (72) to the huge Ca2+ -activated K+ channel (200 pS) ubiquitously distributed in many cells and tissues (
R, Latorre, R, Coronado, C, Vergara
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Are Ions Involved in the Gating of Calcium Channels?
Science, 1982The rates of activation and deactivation of the currents carried by calcium, strontium, or barium ions through the voltage-sensitive calcium channel of Paramecium are different. The differences cannot be attributed to complications due to internal ion concentration, calcium channel inactivation, potassium current ...
Y, Saimi, C, Kung
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Engineering Light-Gated Ion Channels
Biochemistry, 2006Ion channels are gated by a variety of stimuli, including ligands, voltage, membrane tension, temperature, and even light. Natural gates can be altered and augmented using synthetic chemistry and molecular biology to develop channels with completely new functional properties.
Matthew R, Banghart +2 more
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