Results 31 to 40 of about 43,075 (262)
A biomimetic chiral-driven ionic gate constructed by pillar[6]arene-based host–guest systems
Nature Communications, 2018 Uptake and release of glucose is regulated by glucose-sensitive ion channels, but complexity of the system impedes investigation of the gating behavior under physiological conditions.
Yue Sun +9 more
doaj +1 more source
Polyunsaturated fatty acids modify the gating of Kv channels
Frontiers in Pharmacology, 2012 Polyunsaturated fatty acids (PUFAs) have been reported to exhibit antiarrhythmic properties, which are attributed to their capability to modulate ion channels.
Cristina eMoreno +4 more
doaj +1 more source
Optical control of PIEZO1 channels
Nature Communications, 2023 PIEZO proteins are large, mechanically-activated trimeric ion channels. Here the authors report a light-gated mouse PIEZO1 channel, mOP1, whereby an azobenzene-based photoswitch covalently localised at the extracellular apex of a transmembrane helix ...
Francisco Andrés Peralta +8 more
doaj +1 more source
Palmitoylation of Voltage-Gated Ion Channels
International Journal of Molecular Sciences, 2022 Protein lipidation is one of the most common forms of posttranslational modification. This alteration couples different lipids, such as fatty acids, phospho- and glycolipids and sterols, to cellular proteins. Lipidation regulates different aspects of the protein’s physiology, including structure, stability and affinity for cellular membranes and ...
Silvia Cassinelli +5 more
openaire +2 more sources
A nomenclature for ligand-gated ion channels [PDF]
Neuropharmacology, 2009 The ligand-gated ion channels that participate in fast synaptic transmission comprise the nicotinic acetylcholine, 5-hydroxytryptamine3 (5-HT3), gamma-aminobutyric acidA (GABA(A)), glycine, ionotropic glutamate and P2X receptor families. A consistent and systematic nomenclature for the individual subunits that comprise these receptors and the receptors
Collingridge, GL +3 more
openaire +3 more sources
Distinct gating mechanisms revealed by the structures of a multi-ligand gated K+ channel
eLife, 2012 The gating ring-forming RCK domain regulates channel gating in response to various cellular chemical stimuli in eukaryotic Slo channel families and the majority of ligand-gated prokaryotic K+ channels and transporters.
Chunguang Kong +7 more
doaj +1 more source
A binding-block ion selective mechanism revealed by a Na/K selective channel
Protein & Cell, 2017 Mechanosensitive (MS) channels are extensively studied membrane protein for maintaining intracellular homeostasis through translocating solutes and ions across the membrane, but its mechanisms of channel gating and ion selectivity are largely unknown ...
Jie Yu +9 more
doaj +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
FEBS Open Bio, EarlyView.UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source
Molecular mechanism of GIRK2 channel gating modulated by cholesteryl hemisuccinate
Frontiers in PhysiologyCholesterol, an essential lipid of cell membranes, regulates G protein-gated inwardly rectifying potassium (GIRK) channel activity. Previous studies have shown that cholesterol activates GIRK2 homotetrameric channels, which are expressed in dopaminergic ...
Meng Cui +8 more
doaj +1 more source