Results 81 to 90 of about 43,075 (262)
Frontiers in Pharmacology, 2015 Ion selectivity-filter structures are strikingly similar throughout the large family of K+ channels and other p-loop-like receptors (i.e., glutamate receptors). At the same time, the triggers for opening these channels, or gating, are diverse.
Michael eYonkunas, Maria eKurnikova
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Advanced Healthcare Materials, EarlyView.This study investigates the M13 bacteriophage as a biomimetic nanovector capable of crossing in vitro models of the blood–brain barrier. By exploiting peculiar transcellular pathways, M13 avoids lysosomal degradation and preserves its structural integrity and functionality.
Silvia Vercellino +12 more
wiley +1 more source
The RyR1 P3528S Substitution Alters Mouse Skeletal Muscle Contractile Properties and RyR1 Ion Channel Gating. [PDF]
Int J Mol Sci, 2023 Thekkedam CG +4 more
europepmc +1 more source
Advanced Healthcare Materials, EarlyView.This review examines how cellular behavior is regulated by mechanical cues transmitted through soft biomaterials, from single‐cell mechanosensing to tissue‐level adaptation. It highlights why physiological relevance, rather than model complexity alone, is critical for translational mechanobiology and introduces a scoring framework linking material ...
Mathias Polz +9 more
wiley +1 more source
Molecular architecture of the fungal-specific potassium channel TOK1
Nature CommunicationsIn Candida albicans, potassium (K+) channels fine-tune ionic balance under stress, contributing to host colonization. Fungal two-pore domain, outwardly rectifying potassium (TOK) channels remain insufficiently characterized despite evidence implicating ...
Brice Durocher +5 more
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Phase-sensitive detection of anomalous diffusion dynamics in the neuronal membrane induced by ion channel gating. [PDF]
Phys Med Biol, 2023 Choi H +3 more
europepmc +1 more source
Cooperative gating between ion channels
General physiology and biophysics, 2014 Cooperative gating between ion channels, i.e. the gating of one channel directly coupled to the gating of neighboring channels, has been observed in diverse channel types at the single-channel level. Positively coupled gating could enhance channel-mediated signaling while negative coupling may effectively reduce channel gating noise.
openaire +3 more sources
Ion-Channel Gating: Twist to open [PDF]
Current Biology, 1995 Three-dimensional images of the open state of the nicotinic acetylcholine receptor have been obtained at 9 A resolution. Comparison with the closed state reveals the structural basis of channel gating.
openaire +2 more sources
Advanced Healthcare Materials, EarlyView.Gellan gum fluid gel (FG) enables controlled ocular delivery of mesenchymal stromal cell (MSC)‐derived extracellular vesicles (EV). Its shear‐thinning, solid‐liquid‐solid rheology ensures prolonged ocular retention. Sustained MSC‐EV release (∼18% in 6 hrs) supports effective EV ocular delivery.
Seyedmohammad Moosavizadeh +7 more
wiley +1 more source
The Outer Vestibule of the Na+ Channel–Toxin Receptor and Modulator of Permeation as Well as Gating
Marine Drugs, 2010 The outer vestibule of voltage-gated Na+ channels is formed by extracellular loops connecting the S5 and S6 segments of all four domains (“P-loops”), which fold back into the membrane. Classically, this structure has been implicated in the control of ion
René Cervenka +3 more
doaj +1 more source