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Ligand‐Gated Synthetic Ion Channels
Chemistry – A European Journal, 2005AbstractSupramolecular π‐stack architecture is fundamental in DNA chemistry but absent in biological and synthetic ion channels and pores. Here, a novel rigid‐rod π‐stack architecture is introduced to create synthetic ion channels with characteristics that are at the forefront of rational design, that is, ligand gating by a conformational change of the
Talukdar, Pinaki +4 more
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Metal ion effects on ion channel gating
Quarterly Reviews of Biophysics, 20031. Introduction 3742. Metals in biology 3783. The targets: structure and function of ion channels 3804. General effects of metal ions on channels 3824.1 Three types of general effect 3824.2 The main regulators 3835. Effects on gating: mechanisms and models 3845.1 Screening surface charges (Mechanism A) 3875.1.1 The classical approach 3875.1.1.1 ...
Fredrik, Elinder, Peter, Arhem
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Voltage gating of ion channels
Quarterly Reviews of Biophysics, 1994Voltage-gated ion channels are membrane proteins that play a central role in the propagation and transduction of cellular signals (Hille, 1992). Calcium ions entering cells through voltage-gated calcium channels serve as the trigger for neurotransmitter release, muscle contraction, and the release of hormones. Voltage-gated sodium channels initiate the
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Ion Channels: Opening the Gate
Science, 1996A recent paper in Science ( 12 Jan., p. 213 ) and two papers in Neuron (H. P. Larsson et al. , in press, and N. Yang et al. , vol. 16, p. 113) demonstrate that a charged portion of the sodium and potassium ion channel (S4)
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On the opening of voltage-gated ion channels
Physiology & Behavior, 2007Voltage-gated ion channels are key players in fast neuronal signalling. Detailed knowledge about channel gating is essential for our understanding of channel function in general and of drug action of channels in particular. Despite a number of recent atomic channel structures, the opening of voltage-gated channels is the subject of heated debates. Here
Fredrik, Elinder +2 more
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A model of the gating of ion channels
Biochimica et Biophysica Acta (BBA) - Biomembranes, 1988The gating of ion channels in biological membranes has usually been described in terms of Markov transitions between a few discrete open or closed states. Such models predict that the distributions of open and closed durations decay as a sum of exponential terms.
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2021
Abstract Excitable cells, such as neurons and muscles, use ion channels to generate electrical and chemical signals that underlie their functions. Examples include the electrical signals underlying the complex neuronal circuitry in the brain, the secretion of hormones and neurotransmitters, skeletal and cardiac muscle contraction, and ...
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Abstract Excitable cells, such as neurons and muscles, use ion channels to generate electrical and chemical signals that underlie their functions. Examples include the electrical signals underlying the complex neuronal circuitry in the brain, the secretion of hormones and neurotransmitters, skeletal and cardiac muscle contraction, and ...
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Cyclic Nucleotide-Gated Ion Channels
Annual Review of Cell and Developmental Biology, 2003▪ Abstract Cyclic nucleotide-gated (CNG) ion channels were first discovered in rod photoreceptors, where they are responsible for the primary electrical signal of the photoreceptor in response to light. CNG channels are highly specialized membrane proteins that open an ion-permeable pore across the membrane in response to the direct binding of ...
Kimberly, Matulef, William N, Zagotta
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A Light-Gated Synthetic Ion Channel
Organic Letters, 2008A gated synthetic ion channel with beta-cyclodextrin as the pore and azobenzene as the gate is reported. Irradiation converts a tethered trans-azobenzene to cis-azobenzene which likely transforms the channel from a self-inclusion complex to a dissociated structure.
Parag V, Jog, Mary S, Gin
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2008
How and where simple volatile organic molecules act in the central nervous system to cause loss of consciousness and insensitivity to pain has eluded investigation; yet remarkable progress has been made recently towards identifying possible molecular targets through which the mechanism of anesthesia is tranduced.
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How and where simple volatile organic molecules act in the central nervous system to cause loss of consciousness and insensitivity to pain has eluded investigation; yet remarkable progress has been made recently towards identifying possible molecular targets through which the mechanism of anesthesia is tranduced.
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