Results 81 to 90 of about 46,486 (306)
Advanced Functional Materials, EarlyView.A Ti3C2@TiO2 heterostructure has been successfully fabricated by an in situ oxidation approach. The as‐fabricated Ti3C2@TiO2‐based photodetector exhibits narrow‐spectrum response with excellent stability. It also realizes sensitive Cr(VI) detection in a large concentration range of 10−12–10−6 M with an ultra‐low detection limit of 7.6 × 10−12 M ...
Jiahui Hou +11 more
wiley +1 more source
Implications of stochastic ion channel gating and dendritic spine plasticity for neural information processing and storage [PDF]
, 2012 On short timescales, the brain represents, transmits, and processes information through the electrical activity of its neurons. On long timescales, the brain stores information in the strength of the synaptic connections between its neurons.
O'Donnell, Cian
core
Lipid-mediated hydrophobic gating in the BK potassium channel
Nature CommunicationsStructures of the large-conductance, calcium-activated potassium (BK) channel in the Ca2+ −bound and Ca2+ −free states have suggested that K+ conduction is not gated via a steric closure of the pore-lining helices of the channel, in contrast to the ...
Lucia Coronel +4 more
doaj +1 more source
Structure-based membrane dome mechanism for Piezo mechanosensitivity
eLife, 2017 Mechanosensitive ion channels convert external mechanical stimuli into electrochemical signals for critical processes including touch sensation, balance, and cardiovascular regulation. The best understood mechanosensitive channel, MscL, opens a wide pore,
Yusong R Guo, Roderick MacKinnon
doaj +1 more source
Advanced Healthcare Materials, EarlyView.This study investigates the M13 bacteriophage as a biomimetic nanovector capable of crossing in vitro models of the blood–brain barrier. By exploiting peculiar transcellular pathways, M13 avoids lysosomal degradation and preserves its structural integrity and functionality.
Silvia Vercellino +12 more
wiley +1 more source
Natural Biomaterials for Osteochondral Repair: From Source to Strategy
Advanced Healthcare Materials, EarlyView.Biological origin‐guided overview of natural biomaterials and therapeutic strategies for osteochondral tissue engineering. The circular diagram categorizes representative materials and strategies into plant/algae‐derived, microbial‐derived, animal‐derived, and human‐derived sources, centered on an osteochondral defect repair model.
Hengyu Liu +5 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.This review examines how cellular behavior is regulated by mechanical cues transmitted through soft biomaterials, from single‐cell mechanosensing to tissue‐level adaptation. It highlights why physiological relevance, rather than model complexity alone, is critical for translational mechanobiology and introduces a scoring framework linking material ...
Mathias Polz +9 more
wiley +1 more source
Structural changes during ion channel gating
, 2004 Ion channels are generally multi-subunit complexes, with the ion conduction pathway formed at the subunit interface. In moving between the closed and open states, three structurally distinct channels, represented by the recently determined structures of ...
Doyle, Declan A
core
Motifs in the permeation pathway of connexin channels mediate Ca2+ and voltage sensing.
Frontiers in Physiology, 2014 Connexin channels mediate electrical coupling, intercellular molecular signaling and extracellular release of signaling molecules. Connexin proteins assemble intracellularly as hexamers to form plasma membrane hemichannels.
Andrew L. Harris, Jorge E. Contreras
doaj +1 more source
Advanced Healthcare Materials, EarlyView.Gellan gum fluid gel (FG) enables controlled ocular delivery of mesenchymal stromal cell (MSC)‐derived extracellular vesicles (EV). Its shear‐thinning, solid‐liquid‐solid rheology ensures prolonged ocular retention. Sustained MSC‐EV release (∼18% in 6 hrs) supports effective EV ocular delivery.
Seyedmohammad Moosavizadeh +7 more
wiley +1 more source