Results 41 to 50 of about 2,488,331 (299)

The ligand gated ion channel database [PDF]

Nucleic Acids Research, 1999
The ligand gated ion channels (LGICs) are ionotropic receptors to neurotransmitters. Their physiological effect is carried out by the opening of an ionic channel upon binding of a particular neurotransmitter. These LGICs constitute superfamilies of receptors formed by homologous subunits.
Nicolas Le Novère, Jean-Pierre Changeux
openaire   +3 more sources

Site-directed spin labeling reveals pentameric ligand-gated ion channel gating motions. [PDF]

PLoS Biology, 2013
Pentameric ligand-gated ion channels (pLGICs) are neurotransmitter-activated receptors that mediate fast synaptic transmission. In pLGICs, binding of agonist to the extracellular domain triggers a structural rearrangement that leads to the opening of an ...
Cosma D Dellisanti, Borna Ghosh, Susan M Hanson, James M Raspanti, Valerie A Grant, Gaoussou M Diarra, Abby M Schuh, Kenneth Satyshur, Candice S Klug, Cynthia Czajkowski   +9 more
doaj   +1 more source

Palmitoylation of Voltage-Gated Ion Channels

International Journal of Molecular Sciences, 2022
Protein lipidation is one of the most common forms of posttranslational modification. This alteration couples different lipids, such as fatty acids, phospho- and glycolipids and sterols, to cellular proteins. Lipidation regulates different aspects of the protein’s physiology, including structure, stability and affinity for cellular membranes and ...
Silvia Cassinelli, Carla Viñola-Renart, Anna Benavente-Garcia, María Navarro-Pérez, Jesusa Capera, Antonio Felipe   +5 more
openaire   +2 more sources

Structural titration of receptor ion channel GLIC gating by HS-AFM

, 2018
Comment in Direct visualization of ion-channel gating in a native environment. [Proc Natl Acad Sci U S A. 2018]International audienceGloeobacter violaceus ligand-gated ion channel (GLIC), a proton-gated, cation-selective channel, is a prokaryotic ...
Scheuring, Simon, Ruan, Yi, Kao, Kevin, Marchesi, Arin, Hite, Richard, Corringer, Pierre-Jean, Lefebvre, Solène, Marchesi A., Ruan Y., Kao K., Corringer P. -J., Lefebvre S., Hite R. K., Scheuring S.   +13 more
core   +2 more sources

A nomenclature for ligand-gated ion channels [PDF]

Neuropharmacology, 2009
The ligand-gated ion channels that participate in fast synaptic transmission comprise the nicotinic acetylcholine, 5-hydroxytryptamine3 (5-HT3), gamma-aminobutyric acidA (GABA(A)), glycine, ionotropic glutamate and P2X receptor families. A consistent and systematic nomenclature for the individual subunits that comprise these receptors and the receptors
Collingridge, GL, Olsen, RW, Peters, J, Spedding, M   +3 more
openaire   +3 more sources

Distinct gating mechanisms revealed by the structures of a multi-ligand gated K+ channel

eLife, 2012
The gating ring-forming RCK domain regulates channel gating in response to various cellular chemical stimuli in eukaryotic Slo channel families and the majority of ligand-gated prokaryotic K+ channels and transporters.
Chunguang Kong, Weizhong Zeng, Sheng Ye, Liping Chen, David Bryant Sauer, Yeeling Lam, Mehabaw Getahun Derebe, Youxing Jiang   +7 more
doaj   +1 more source

A binding-block ion selective mechanism revealed by a Na/K selective channel

Protein & Cell, 2017
Mechanosensitive (MS) channels are extensively studied membrane protein for maintaining intracellular homeostasis through translocating solutes and ions across the membrane, but its mechanisms of channel gating and ion selectivity are largely unknown ...
Jie Yu, Bing Zhang, Yixiao Zhang, Cong-qiao Xu, Wei Zhuo, Jingpeng Ge, Jun Li, Ning Gao, Yang Li, Maojun Yang   +9 more
doaj   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Strict coupling between CFTR's catalytic cycle and gating of its Cl- ion pore revealed by distributions of open channel burst durations [PDF]

, 2010
CFTR, the ABC protein defective in cystic fibrosis, functions as an anion channel. Once phosphorylated by protein kinase A, a CFTR channel is opened and closed by events at its two cytosolic nucleotide binding domains (NBDs).
Gadsby, DC, Csanady, L, Vergani, P
core  

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source