American Journal of Medical Genetics Part A, EarlyView.ABSTRACT Cytosolic phosphoenoylpyruvate carboxykinase (PEPCK‐C) is an essential, rate‐limiting enzyme in the gluconeogenesis pathway. PEPCK‐C deficiency presents with hypoglycaemia, hyperlactataemia and hepatopathy, and was first reported in association with bi‐allelic PCK1 variants in 2014.
Isaac Bernhardt +9 more
wiley +1 more source
Alkyltransferase Ribozyme for Site‐Specific N4‐Cytidine Alkylation
Angewandte Chemie, EarlyView.CSAR is the first ribozyme that catalyzes direct alkylation of an exocyclic amino group of an RNA nucleobase. The ribozyme was isolated as a self‐labeling catalyst from an in vitro selection library and engineered into a trans‐active ribozyme that catalyzes the transfer of a benzyl group from an O6‐modifed guanine to the N4 amino group of a specific ...
Evgeniia Dorinova +2 more
wiley +2 more sources
Spin‐State Modulation of Atomic Iron Sites Enables Efficient CO2 Electroreduction in Acid Medium
Angewandte Chemie, EarlyView.An axial oxygen ligand was added to shift the spin state of the single‐atom Fe site from low to medium spin. This change reduces the interfacial interaction with H3O+ and decreases the *CO desorption energy, thus enhancing CO2RR in acidic media.
Shanhe Gong +13 more
wiley +2 more sources
Mechanically Activated Luminescence in Polyurethanes Incorporating Calixarene Mechanophores
Angewandte Chemie, EarlyView.The conformational flexibility of a calix[4]arene is exploited to obtain a reversible mechanoluminophore featuring a pyrene excimer couple at the upper rim. Stretching a linear polyurethane incorporating such mechanophore results in luminescence color change from yellow–green to blue, consistent with a force‐induced conformational motion of the ...
Lucia Visieri +3 more
wiley +2 more sources
Sodium Ion Effect on Separation Of Butyrylcholinesterase from Plasma by Ion-Exchange Chromatography. [PDF]
Curr Health Sci J, 2015 Postoarca AG +4 more
europepmc +1 more source
Spurious Elevation of Multiple Urine Amino Acids by Ion-Exchange Chromatography in Patients with Prolidase Deficiency. [PDF]
JIMD Rep, 2017 Ferreira CR, Cusmano-Ozog K.
europepmc +1 more source
Comparison between polymerized ionic liquids synthesized using chain-growth and step-growth mechanisms used as stationary phase in gas chromatography [PDF]
, 2016 David, Frank +2 more
core +1 more source
Authors' reply. Haemoglobin variant and falsely high haemoglobin A1c value on ion-exchange chromatography. [PDF]
Singapore Med J, 2014 Chen CF, Tai YK.
europepmc +1 more source
A Synergistic Inhibitor Development Strategy Against Human UDP‐Galactose‐4‐Epimerase
Angewandte Chemie International Edition, EarlyView.The epimerase GalE is crucial for the biosynthesis of cancer‐relevant O‐GalNAc glycans. Here, we employ orthogonal, structurally enabled small molecule fragment screens to yield both covalent and non‐covalent inhibitors against GalE within no more than 22 elaborated compounds.
William M. Browne +22 more
wiley +1 more source