Results 201 to 210 of about 462,385 (285)

Discovery of a Reversible Sub‐Picomolar Thrombin Inhibitor Using DCC

Angewandte Chemie, EarlyView.
An ultrapotent yet fully reversible trivalent thrombin inhibitor discovered through screening a large dynamic combinatorial library (DCL) of 125 000 members of self‐assembled fragments. The innovative approach leverages size‐exclusion‐based affinity selection, coupled with MALDI‐TOF mass spectrometry readout, enabling the full workflow to be completed ...
Millicent Dockerill, Richard J. Payne, Nicolas Winssinger   +2 more
wiley   +1 more source

Kinetically Stable Boron‐Heteroatom Bonds

Angewandte Chemie, EarlyView.
This study investigates the kinetic stability of boron‐heteroatom bonds in N‐methyliminodiacetic acid (MIDA) boronates. The hemilabile nature of the ligand enables the synthesis of molecules that would otherwise be considered too hydrolytically labile. Depending on the structure, acid‐promoted migration of the boryl group was found to produce compounds
Alina Trofimova, Ben Zhen Huang, Harjeet S. Soor, Brandon White, Aleksandra Holownia, Yury Lebedev, Alan J. Lough, Travis Dudding, Andrei K. Yudin   +8 more
wiley   +1 more source

The Production and Purification of Therapeutic Antibodies: A Comprehensive Analysis of Process- and Product-Related Contaminants. [PDF]

Biomolecules
James K, Kovac A, Majerova P.
europepmc   +1 more source

Inverse Vulcanization Through Epoxide Chemistry: A Low Temperature Non‐Olefin Route to Sulfur‐Rich Polymer Networks

Angewandte Chemie, EarlyView.
Epoxide monomers undergo base‐catalyzed ring‐opening copolymerization with elemental sulfur to afford sulfur‐rich polymers under mild conditions. The resulting materials exhibit excellent mechanical performance, strong adhesion (up to 10 MPa on stainless steel), and outstanding reprocessability.
Pan Yang, Youfu Wang, Xinyuan Zhu, Jinhong Jia, Xiaofeng Wu, Tom Hasell   +5 more
wiley   +1 more source

Mechanistic Insights Into the Retention and Separation Mechanism of Poly(Ethylene Glycol)-Modified Short Oligonucleotides in Anion-Exchange Chromatography. [PDF]

Biotechnol J
Yoshimoto N, Matsumoto T, Ono Y, Kumagai Y.   +3 more
europepmc   +1 more source

Complementary Quantitation of Inorganic Counterions and Organic Components Using ICP OES and qNMR for Organo-Sulfonic Salts. [PDF]

ACS Omega
Imaoka M, Takada S, Kurohara T, Tatebe C, Fujiwara Y, Fujihara K, Kawasue S, Ohtsuki T, Tada A, Matsufuji H, Sugimoto N.   +10 more
europepmc   +1 more source

Development of surfactin-based nanocarrier for targeted doxorubicin delivery. [PDF]

Sci Rep
Mahareek O, Mousa NO, Mamdouh S, El-Zayat EM, Okasha H.   +4 more
europepmc   +1 more source

Radiation stability and performance of TEHDGA resin for theranostic scandium radionuclide purification. [PDF]

EJNMMI Radiopharm Chem
Zabolockis RJ, Mamis E, Pakalniete LD, Avotina L, Bertins M, Sadauskis J, Semjonova A, Sadło J, Rzepna M, Proskurins J, Pajuste E.   +10 more
europepmc   +1 more source

Evaluation of LC/MS Methods for Hydrophilic Metabolites to Enable Integration of Human Blood Metabolome Data. [PDF]

Mass Spectrom (Tokyo)
Imado Y, Takahashi M, Soma Y, Aburaya S, Nakatani K, Hanai T, Bamba T, Izumi Y.   +7 more
europepmc   +1 more source

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Robust mechanistic modeling of protein ion-exchange chromatography.

Journal of Chromatography A, 2021
Mechanistic models for ion-exchange chromatography of proteins are well-established and a broad consensus exists on most aspects of the detailed mathematical and physical description. A variety of specializations of these models can typically capture the
Vijesh Kumar, Samuel Leweke, W. Heymann, E. von Lieres, F. Schlegel, Karin Westerberg, A. Lenhoff   +6 more
semanticscholar   +1 more source