Results 61 to 70 of about 533,409 (280)
A space-fractional cable equation for the propagation of action potentials in myelinated neurons [PDF]
, 2020 Myelinated neurons are characterized by the presence of myelin, a multilaminated wrapping around the axons formed by specialized neuroglial cells. Myelin acts as an electrical insulator and therefore, in myelinated neurons, the action potentials do not ...
Drapaca, Corina S. +2 more
core +2 more sources
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Exomer Is Part of a Hub Where Polarized Secretion and Ionic Stress Connect
Frontiers in Microbiology, 2021 Plasma membrane and membranous organelles contribute to the physiology of the Eukaryotic cell by participating in vesicle trafficking and the maintenance of ion homeostasis.
Sandra Moro +9 more
doaj +1 more source
Executive Privilege in the Federal Courts [PDF]
, 1962 Apoptosis is one type of programmed cell death, important during tissue development and to maintain the tissue homeostasis. Apoptosis comprises a complex network of internal signaling pathways, and an important part of this signaling network is the ...
null null, Ulrika Englund
core +2 more sources
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Frontiers in Plant Science, 2020 Brassinolide (BL) mediates various physiological processes and improves plant tolerance to abiotic stresses. However, the effects and mechanism of exogenous BL on the salt tolerance of apple seedlings remain unclear.
Qiufang Su +7 more
doaj +1 more source
Quantitative RNA-seq Analysis Unveils Osmotic and Thermal Adaptation Mechanisms Relevant for Ectoine Production in Chromohalobacter salexigens [PDF]
, 2018 Quantitative RNA sequencing (RNA-seq) and the complementary phenotypic assays were implemented to investigate the transcriptional responses of Chromohalobacter salexigens to osmotic and heat stress.
Carmen Vargas +6 more
core +2 more sources
Channeling dysglycemia: ion-channel variations perturbing glucose homeostasis [PDF]
Trends in Endocrinology & Metabolism, 2012 Maintaining blood glucose homeostasis is a complex process that depends on pancreatic islet hormone secretion. Hormone secretion from islets is coupled to calcium entry which results from regenerative islet cell electrical activity. Therefore, the ionic mechanisms that regulate calcium entry into islet cells are crucial for maintaining normal glucose ...
Jerod Scott, Denton +1 more
openaire +2 more sources
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
A Multidomain Model for Ionic Electrodiffusion and Osmosis with an Application to Cortical Spreading Depression [PDF]
, 2014 Ionic electrodiffusion and osmotic water flow are central processes in many physiological systems. We formulate a system of partial differential equations that governs ion movement and water flow in biological tissue.
Mori, Yoichiro
core