Results 71 to 80 of about 117,477 (313)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Fabrication of a side aligned optical fibre inteferometer by focused ion beam machining [PDF]

, 2013
Focused ion beam (FIB) machining is a promising technique for the fabrication of micro-optical components with high quality surface finishes. In this work, a prototype of a side aligned optical fibre interferometer was successfully fabricated by the ...
Ritchie, J. M., Maier, R R J, Li, J, Hand, D P; id_orcid, Luo, X, Hand, D P, Sun, J, MacPherson, W. N., Luo, Xichun, Ritchie, J M, Macpherson, W N; id_orcid, Miller, M K, Maier, R R J; id_orcid, sun, jining   +13 more
core   +1 more source

Photothermal Performance Testing of Lithium Niobate After Ion Beam Radiation

Photonics
To investigate the evolution of the optothermal properties of lithium niobate with ion beam irradiation parameters, the thermal effect theory was analyzed, and ion beam irradiation technology was used to modify lithium niobate samples.
Junyi Liu, Daiyong Lin, Xing Peng, Yao Wu, Jian Li, Ziqiang Hu, Zhixuan He, Jiaqi Wang, Yuxia Tan, Xiaoshu Xu, Shuo Qiao   +10 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Ion track formation via electric-field-enhanced energy deposition

Physical Review Research
High-energy ion irradiation deposits extreme energy in a narrow range (∼1–10 nm) along ion trajectories in solid through electronic energy loss, producing unique irradiation effects such as ion tracks.
Zikang Ge, Jinhao Hu, Shengyuan Peng, Wei Kang, Xiaofei Shen, Yanbo Xie, Jianming Xue   +6 more
doaj   +1 more source

Irradiation Effect of Argon Ion on Interfacial Structure Fe(2nm)/Si(tsi=0.5-2 nm) Multilayer thin Film

Atom Indonesia, 2010
Investigation includes formation of interfacial structure of Fe(2nm)/Si(tSi= 0.5-2 nm) multilayer thin film and the behavior of antiferromagnetic coupling between Fe layers due to Argon ion irradiation was investigated.
S. Purwanto
doaj   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Retrieval of B1 phase from high-pressure B2 phase for CdO nanoparticles by electronic excitations in CdxZn1−xO composite thin films

Beilstein Journal of Nanotechnology
This study investigates the recovery of the B1 phase from the high-pressure B2 phase, at atmospheric pressure, in cadmium oxide (CdO) nanoparticles incorporated within sol–gel synthesized CdxZn1−xO (x = 0.40) composite thin films. The recovery process is
Arkaprava Das, Marcin Zając, Carla Bittencourt   +2 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source