Results 51 to 60 of about 1,540,089 (252)

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Control of magnetoelastic coupling in Ni/Fe multilayers using He + ion irradiation

, 2022
International audienceThis study reports the effects of post-growth He + irradiation on the magneto-elastic properties of a Ni/Fe multi-layered stack. The progressive intermixing caused by He + irradiation at the interfaces of the multilayer allows us to
Verheijen, Marcel, Koopmans, Bert, Lavrijsen, Reinoud, Li, Pingzhi, van der Jagt, Johannes, Juge, Roméo, Ravelosona, Dafiné, Hintermayr, Julian, Bruikman, René, Beens, Maarten, Barcones, Beatriz   +10 more
core   +1 more source

Postsynaptic density radiation signature following space irradiation

Frontiers in Physiology, 2023
Introduction: The response of the brain to space radiation is an important concern for astronauts during space missions. Therefore, we assessed the response of the brain to 28Si ion irradiation (600 MeV/n), a heavy ion present in the space environment ...
Soren Impey, Soren Impey, Carl Pelz, Lara-Kirstie Riparip, Amanuel Tafessu, Fatema Fareh, Damian G. Zuloaga, Tessa Marzulla, Blair Stewart, Susanna Rosi, Mitchell S. Turker, Jacob Raber, Jacob Raber   +12 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Photothermal Performance Testing of Lithium Niobate After Ion Beam Radiation

Photonics
To investigate the evolution of the optothermal properties of lithium niobate with ion beam irradiation parameters, the thermal effect theory was analyzed, and ion beam irradiation technology was used to modify lithium niobate samples.
Junyi Liu, Daiyong Lin, Xing Peng, Yao Wu, Jian Li, Ziqiang Hu, Zhixuan He, Jiaqi Wang, Yuxia Tan, Xiaoshu Xu, Shuo Qiao   +10 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Morphology modification of Si nanopillars under ion irradiation at elevated temperatures: plastic deformation and controlled thinning to 10 nm

, 2019
International audienceSi nanopillars of less than 50 nm diameter have been irradiated in a helium ion microscope with a focused Ne + beam. The morphological changes due to ion beam irradiation at room temperature and elevated temperatures have been ...
Heinig, Karl-Heinz, Borany, Johannes, Von, Hlawacek, Gregor, Xu, Xiaomo, Tiron, Raluca, Klingner, Nico, Gharbi, Ahmed, Engelmann, Hans-Jürgen, Möller, Wolfhard   +8 more
core   +1 more source

Helium irradiation effects in polycrystalline Si, silica, and single crystal Si [PDF]

, 2012
Transmission electron microscopy (TEM) has been used to investigate the effects of room temperature 6 keV helium ion irradiation of a thin (≈55 nm thick) tri-layer consisting of polycrystalline Si, silica, and single-crystal Si.
Greaves, Graeme, Ward, M. B., Pawley, C. J., Abrams, K. J., Hinks, J. A., K. J. Abrams, D. Eyidi, G. Greaves, Greaves, G., Van den Berg, Jakob, S. E. Donnelly, Van Den Berg, J. A., Eyidi, D., Donnelly, S. E., J. A. Hinks, J. A. van den Berg, C. J. Pawley, M. B. Ward   +17 more
core   +1 more source

Fast recovery of ion-irradiation-induced defects in Ge2Sb2Te5 thin films at room temperature

, 2021
Phase-change materials serve a broad field of applications ranging from non-volatile electronic memory to optical data storage by providing reversible, repeatable, and rapid switching between amorphous and crystalline states accompanied by large changes ...
Jura Rensberg (1394461), Robin Schock (11370363), Carsten Ronning (1359846), Mikhail A. Kats (1394470), Chenghao Wan (4815432), Martin Hafermann (6057434)   +5 more
core   +1 more source