Results 31 to 40 of about 1,540,089 (252)

Carbon-ion beam irradiation kills X-ray-resistant p53-null cancer cells by inducing mitotic catastrophe.

PLoS ONE, 2014
Background and purposeTo understand the mechanisms involved in the strong killing effect of carbon-ion beam irradiation on cancer cells with TP53 tumor suppressor gene deficiencies.Materials and methodsDNA damage responses after carbon-ion beam or X-ray ...
Napapat Amornwichet, Takahiro Oike, Atsushi Shibata, Hideaki Ogiwara, Naoto Tsuchiya, Motohiro Yamauchi, Yuka Saitoh, Ryota Sekine, Mayu Isono, Yukari Yoshida, Tatsuya Ohno, Takashi Kohno, Takashi Nakano   +12 more
doaj   +1 more source

A Link between Neutron and Ion Irradiation Hardening for Stainless Austenitic and Ferritic-Martensitic Steels

Metals
Radiation hardening is studied for stainless austenitic and ferritic-martensitic chromium steels after ion and neutron irradiation at various temperatures. Austenitic and ferritic-martensitic steels irradiated up to 30 dpa in various nuclear reactors and
Boris Margolin, Alexander Sorokin, Lyubov Belyaeva   +2 more
doaj   +1 more source

Superior Effect of the Combination of Carbon-Ion Beam Irradiation and 5-Fluorouracil on Colorectal Cancer Stem Cells in vitro and in vivo

, 2020
Background: The aim of this study was to investigate whether carbon-ion beam irradiation in combination with 5-fluorouracil (5-FU) is superior to carbon-ion beam irradiation alone in targeting colorectal cancer stem-like cells (CSCs).
Masao, Suzuki, 1006039, Hirohiko, Tsujii, 1006038, Fujimori, Akira, Shigeru, Yamada, Sai, Sei, Sei, Sai, 1006040, Tsujii, Hirohiko, Akira, Fujimori, Sub Koom, Woong, 1006037, Suzuki, Masao, 1006047, Yamada, Shigeru, 1006046, 1006045, 1006044, 1006043, 1006042, 1006041   +21 more
core   +1 more source

Biological Effect and Molecular Mechanism of Heavy Ion Irradiation on Human Tongue Squamous Cell Carcinoma CAL27 Cells

Zhongliu Fangzhi Yanjiu, 2018
Objective The biological effect and molecular mechanism of heavy ion 12C6+ ion irradiation on human tongue squamous cell carcinoma CAL27 cells. Methods We applied different doses of heavy ion beam (12C6+) to irradiate in vitro cultured human tongue ...
LIU Yali, WANG Zhiqiang, MA Lijuan, WANG Ruoyu, YANG Lan, FENG Zhenghu   +5 more
doaj   +1 more source

DNA-PKcs inhibition sensitizes cancer cells to carbon-ion irradiation via telomere capping disruption. [PDF]

PLoS ONE, 2013
Heavy-ion irradiation induces a higher frequency of DNA double strand breaks (DSBs) which must be properly repaired. Critical shortening of telomeres can trigger DNA damage responses such as DSBs.
Xin Zhou, Xin Zhang, Yi Xie, Kaoru Tanaka, Bing Wang, Hong Zhang   +5 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

In vitro evaluation of photon and carbon ion radiotherapy in combination with cisplatin in head and neck squamous cell carcinoma cell lines

Frontiers in Oncology, 2023
BackgroundHeavy ion radiotherapy, such as carbon ion radiotherapy (CIRT), has multiple advantages over conventional photon therapy. Cisplatin, as a classic anti-tumor drugs, has been tested and discovered as a photon radiosensitizer in several cell lines,
Xumeng Fang, Xumeng Fang, Xumeng Fang, Pian Sun, Pian Sun, Pian Sun, Yuanli Dong, Yuanli Dong, Yuanli Dong, Yangle Huang, Yangle Huang, Yangle Huang, Jiade Jay Lu, Jiade Jay Lu, Jiade Jay Lu, Lin Kong, Lin Kong, Lin Kong   +17 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

The investigation of the carbon on irradiation hardening and defect clustering in RPV model alloy using ion irradiation and OKMC simulation

Nuclear Engineering and Technology
The precipitation of solutes is a major cause of irradiation hardening and embrittlement limiting the service life of reactor pressure vessel (RPV) steels. Impurities play a significant role in the formation of precipitation in RPV materials.
Yitao Yang, Jianyang Li, Chonghong Zhang
doaj   +1 more source