Results 221 to 230 of about 38,937 (242)

Ion mobility mass spectrometry of human melanoma gangliosides

Biochimie, 2020
Malignant melanoma is an aggressive type of skin cancer, rarely detected in the early stages. Various sets of methods and techniques, including dermatoscopical inspection of the "ABCDE" signs of the lesion, imaging techniques or microscopical, immunohistochemical and serological biomarkers are available and used nowadays to diagnose malignant melanoma.
Mirela, Sarbu, David E, Clemmer, Alina D, Zamfir   +2 more
openaire   +2 more sources

Characterizing Oligosaccharides Using Injected-Ion Mobility/Mass Spectrometry

Analytical Chemistry, 1997
Injected-ion mobility/mass spectrometry techniques have been used to measure the reduced ion mobilities for negatively charged raffinose, melezitose and α-, β-, and γ-cyclodextrins formed by electrospray ionization. At low injection energies, the mass spectra are dominated by negatively charged (deprotonated) parent ions.
Y, Liu, D E, Clemmer
openaire   +2 more sources

Trends in trapped ion mobility – Mass spectrometry instrumentation

TrAC Trends in Analytical Chemistry, 2019
Abstract Trapped Ion Mobility Spectrometry (TIMS) is a recently developed form of ion mobility spectrometry (IMS) which is flexible in its operation and readily hybridized with mass spectrometry (MS). Prototype TIMS-MS instruments are applicable to a wide range of analytical problems including separation of isobars and isomers, the study of analyte ...
Mark E. Ridgeway, Christian Bleiholder, Matthias Mann, Melvin A. Park   +3 more
openaire   +2 more sources

Ion Mobility Mass Spectrometry Analysis of Human Glycourinome

Analytical Chemistry, 2008
Complex carbohydrates are macromolecules biosynthesized in nontemplate-type processes, bearing specific glycoepitopes involved in crucial recognition processes such as cell differentiation and cell-cell interactions. Chemical structure of single components in complex mixtures can be analyzed by mass spectrometry for determination of the size and ...
Sergey Y, Vakhrushev, James, Langridge, Iain, Campuzano, Chris, Hughes, Jasna, Peter-Katalinić   +4 more
openaire   +2 more sources

Biomolecular structural separations by ion mobility–mass spectrometry

Analytical and Bioanalytical Chemistry, 2008
Following the paradigm of the human genome project, much of current systems biology research entails characterizing, quantifying, and cataloging the biomolecular inventory of a sample at specific dimensions of space (e.g., cellular, tissue, or organism levels) and time (e.g., point in the life cycle, healthy vs. diseased state).
Larissa S, Fenn, John A, McLean
openaire   +2 more sources

Contemporary glycomic approaches using ion mobility–mass spectrometry

Current Opinion in Chemical Biology, 2018
Characterization of complex oligosaccharides has historically required extensive sample handling and separations before analysis using nuclear magnetic resonance spectroscopy and electron impact mass spectra following hydrolysis, derivatization, and gas chromatographic separation.
Kelsey A, Morrison, Brian H, Clowers
openaire   +2 more sources

Ion mobility mass spectrometry of proteins and proteinassemblies

Chem. Soc. Rev., 2010
Traditionally, mass spectrometry has been a powerful analytical method enabling the structural analysis of small molecules, and later on peptides and proteins. With the advent of native mass spectrometry, using a combination of electrospray ionisation and time of flight analysis, mass spectrometry could also be applied to the mass determination of ...
Uetrecht, C., Rose, R.J., van Duijn, E., Lorenzen, K., Heck, A.J.R.   +4 more
openaire   +3 more sources

Ion mobility spectrometry and ion mobility-mass spectrometry in clinical chemistry

Advancements in clinical chemistry have major implications in terms of public health, prompting many clinicians to seek out chemical information to aid in diagnoses and treatments. While mass spectrometry (MS) and hyphenated-MS techniques such as LC-MS or tandem MS/MS have long been the analytical methods of choice for many clinical applications, these
Kyle E, Lira, Jody C, May, John A, McLean   +2 more
openaire   +2 more sources

Application of Ion Mobility Mass Spectrometry in Lipidomics

2019
Lipids play significant roles in biological system, and the study of lipid metabolisms may provide a new insight into the diagnosis and pathophysiology of diseases. Recent developments in high-resolution mass spectrometry techniques combined with high-performance chromatographic methods provide deep insight into lipid analysis. Addition of ion mobility
Fereshteh, Zandkarimi, Lewis M, Brown
openaire   +2 more sources

Ion Mobility Mass Spectrometry

The Analyst, 2015
Barran, P, Ruotolo, B
openaire   +2 more sources