Results 21 to 30 of about 38,937 (242)

Protein shape sampled by ion mobility mass spectrometry consistently improves protein structure prediction

open access: yesNature Communications, 2022
Collision cross sections (CCS) from ion mobility mass spectrometry provide information about protein shape and size. Here, the authors develop an algorithm to predict CCS and integrate experimental ion mobility data into Rosetta-based molecular modelling
SM Bargeen Alam Turzo   +7 more
doaj   +1 more source

Recent Progress in Protein Stereochemical Modifications Revealed by Ion Mobility-Mass Spectrometry [PDF]

open access: yesZhipu Xuebao, 2022
Protein stereochemical modification (SCM) is a unique type of low-abundance post-translational modification associated with many human diseases. Because it does not change the molecular weight of proteins, traditional proteomics methods are generally not
XU Xia1   +3 more
doaj   +1 more source

Glycan Analysis by Ion Mobility–Mass Spectrometry [PDF]

open access: yesAngewandte Chemie International Edition, 2017
AbstractCarbohydrates form one of the major classes of biological macromolecules in living organisms. To investigate their properties and function, an in‐depth knowledge of their underlying structure is essential. However, the inherent structural complexity of glycans represents a major challenge.
Johanna Hofmann, Kevin Pagel
openaire   +3 more sources

A Cyclic Ion Mobility-Mass Spectrometry System [PDF]

open access: yesAnalytical Chemistry, 2019
Improvements in the performance and availability of commercial instrumentation have made ion mobility-mass spectrometry (IM-MS) an increasingly popular approach for the structural analysis of ionic species as well as for separation of complex mixtures. Here, a new research instrument is presented which enables complex experiments, extending the current
Kevin Giles   +6 more
openaire   +2 more sources

Ion Mobility-Mass Spectrometry: Time-Dispersive Instrumentation [PDF]

open access: yesAnalytical Chemistry, 2015
The field of ion mobility-mass spectrometry (IM-MS) has grown with significant momentum in recent years in both fundamental advances and pioneering applications. A search of the terms “ion mobility” and “mass spectrometry” returns more than 2 000 papers, with over half of these being published in the past 4 years (Figure ​(Figure1,1, left).
May, Jody C., McLean, John A.
openaire   +2 more sources

Differential ion mobility mass spectrometry in immunopeptidomics identifies neoantigens carrying colorectal cancer driver mutations

open access: yesCommunications Biology, 2022
An optimized method for mass spectrometry based immunopeptidomics analysis using high-field asymmetric waveform ion mobility spectrometry is presented and identifies 44,815 HLA-bound peptides (HLAp) from colorectal cancer samples.
Yuriko Minegishi   +8 more
doaj   +1 more source

Separation Abilities of Capillary Electrophoresis Coupled with Ion Mobility Mass Spectrometry for the Discrete Detection of Sequence Isomeric Peptides

open access: yesSeparations, 2022
The separation and discrete detection of isomeric sequence peptides with similar properties are important tasks for analytical science. Three different peptide isomers of 12 amino-acid residues long, containing direct and reverse regions of the alanine ...
Yury E. Glazyrin   +3 more
doaj   +1 more source

Recent Advances of Native Mass Spectrometry Techniques [PDF]

open access: yesZhipu Xuebao, 2022
Nearly all the life activities are regulated by the interactions of the protein with other biomolecules, including protein-protein interactions (PPIs) and protein-ligand interactions (PLIs), therefore understanding interaction and structural ...
TAN Cong-rui;XU Wei
doaj   +1 more source

Comprehensive spectral libraries for various rabbit eye tissue proteomes

open access: yesScientific Data, 2022
Measurement(s) database type spectral library Technology Type(s) ion mobility spectrometry-mass spectrometry Sample Characteristic - Organism Oryctolagus cuniculus Sample Characteristic - Environment eye Sample Characteristic - Location United States of ...
Guoting Qin   +4 more
doaj   +1 more source

Evaluating Software Tools for Lipid Identification from Ion Mobility Spectrometry–Mass Spectrometry Lipidomics Data

open access: yesMolecules, 2023
The unambiguous identification of lipids is a critical component of lipidomics studies and greatly impacts the interpretation and significance of analyses as well as the ultimate biological understandings derived from measurements.
Dylan H. Ross   +5 more
doaj   +1 more source

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