Results 71 to 80 of about 390,019 (267)

Ion channels and transporters in metastasis

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2015
An elaborate interplay between ion channels and transporters, components of the cytoskeleton, adhesion molecules, and signaling cascades provides the basis for each major step of the metastatic cascade. Ion channels and transporters contribute to cell motility by letting through or transporting ions essential for local Ca2+, pH and--in cooperation with
Stock, Christian, Schwab, Albrecht
openaire   +2 more sources

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source

Ion transport and the vibrating probe

Biophysical Journal, 1986
The theory of ion transport in the vicinity of a vibrating probe is developed. It is shown that the convection loops produced by the probe will not affect the electrical current density, assuming that the action of the probe does not affect the sources of the current in the biological system.
Ferrier, J., Lucas, W.J.
openaire   +2 more sources

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Ion transport on phased radiofrequency carpets in xenon gas

European Physical Journal C: Particles and Fields
We present the design and performance of a four-phased radiofrequency (RF) carpet system for ion transport between 200–600 mbar, significantly higher than previously demonstrated RF carpet applications.
E. Dey, B. J. P. Jones, Y. Mei, M. Brodeur, V. A. Chirayath, N. Coward, F. W. Foss, K. E. Navarro, I. Parmaksiz, C. Adams, H. Almazán, V. Álvarez, B. Aparicio, A. I. Aranburu, L. Arazi, I. J. Arnquist, F. Auria-Luna, S. Ayet, C. D. R. Azevedo, K. Bailey, F. Ballester, M. del Barrio-Torregrosa, A. Bayo, J. M. Benlloch-Rodríguez, F. I. G. M. Borges, A. Brodolin, N. Byrnes, S. Cárcel, A. Castillo, E. Church, L. Cid, C. A. N. Conde, T. Contreras, F. P. Cossío, R. Coupe, G. Díaz, C. Echevarria, M. Elorza, J. Escada, R. Esteve, R. Felkai, L. M. P. Fernandes, P. Ferrario, A. L. Ferreira, Z. Freixa, J. García-Barrena, J. J. Gómez-Cadenas, J. W. R. Grocott, R. Guenette, J. Hauptman, C. A. O. Henriques, J. A. Hernando Morata, P. Herrero-Gómez, V. Herrero, C. Hervés Carrete, Y. Ifergan, F. Kellerer, L. Larizgoitia, A. Larumbe, P. Lebrun, F. Lopez, N. López-March, R. Madigan, R. D. P. Mano, A. P. Marques, J. Martín-Albo, G. Martínez-Lema, M. Martínez-Vara, R. L. Miller, K. Mistry, J. Molina-Canteras, F. Monrabal, C. M. B. Monteiro, F. J. Mora, P. Novella, A. Nuñez, D. R. Nygren, E. Oblak, J. Palacio, B. Palmeiro, A. Para, A. Pazos, J. Pelegrin, M. Pérez Maneiro, M. Querol, J. Renner, I. Rivilla, C. Rogero, L. Rogers, B. Romeo, C. Romo-Luque, V. San Nacienciano, F. P. Santos, J. M. F. dos Santos, M. Seemann, I. Shomroni, P. A. O. C. Silva, A. Simón, S. R. Soleti, M. Sorel, J. Soto-Oton, J. M. R. Teixeira, S. Teruel-Pardo, J. F. Toledo, C. Tonnelé, S. Torelli, J. Torrent, A. Trettin, A. Usón, P. R. G. Valle, J. F. C. A. Veloso, J. Waiton, A. Yubero-Navarro   +112 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source