Results 71 to 80 of about 1,261,670 (349)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Numerical Study of Salt Ion Transport in Electromembrane Systems with Ion-Exchange Membranes Having Geometrically Structured Surfaces

Mathematics
This article is devoted to numerically modeling the effect of the geometric modification of the surfaces of ion-exchange membranes in electromembrane systems (EMSs) on the salt ion transport using a 2D mathematical model of the transport process in the ...
Evgenia Kirillova, Natalia Chubyr, Anna Kovalenko, Mahamet Urtenov   +3 more
doaj   +1 more source

Carrier-mediated ferromagnetic ordering in Mn ion-implanted p+GaAs:C

, 2003
Highly p-type GaAs:C was ion-implanted with Mn at differing doses to produce Mn concentrations in the 1 - 5 at.% range. In comparison to LT-GaAs and n+GaAs:Si samples implanted under the same conditions, transport and magnetic properties show marked ...
A. Kaminski, C. R. Abernathy, C.R. Abernathy, C.R. Abernathy, D. Ferrand, D.R. Schmidt, E.F. Schubert, H. Akinaga, H. Munekata, H. Ohldag, H. Ohno, H. Ohno, H. Ohno, J-P. Bouchaud, J. D. Lim, J. De Boeck, J. S. Lee, J. Shi, K. S. Suh, K.C. Ku, K.W. Edmonds, M. Berciu, M. Moreno, M.A. Scarpulla, N. Theodoropoulou, P.A. Korzhavyi, R. G. Wilson, R.N. Bhatt, S. B. Shim, S. J. Pearton, S.A. Wolf, S.J. Pearton, S.J. Pearton, S.J. Potashnik, T. Hayashi, T. Jungwirth, T. Jungwirth, T. Kanomata, W. Li, Y. D. Park, Y. Iye, Y. S. Kim, Y. Satoh, Y.D. Park, Y.D. Park, Z. G. Khim   +45 more
core   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Assessment of the Risks Associated with the Handling and Transportation of Air Shipments Containing Lithium-Ion Batteries

Energies
Air transport, in addition to passenger transport, also transports air shipments containing hazardous materials. Hazardous materials include lithium-ion batteries, which can be carried both by passengers and by cargo aircraft.
Anna Kwasiborska, Sylwia Ścigaj
doaj   +1 more source

Extraction and low energy transport of negative ions [PDF]

, 2005
High perveance negative ion beams with low emittance are essential for several next generation particle accelerators (i. g. spallation sources like ESS [1] and SNS [2]).
Jakob, Ansgar, Klein, Horst, Lakatos, Andreas, Pozimski, Jürgen   +3 more
core  

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Disentangling cation effects on ion mobility and structure in ionic liquid electrolytes

JPhys Energy
Ionic liquids (ILs) are low-temperature molten salts, where ion transport is primarily governed by ion–ion interactions. Yet, the impact of organic IL cations on critical electrolyte properties such as ion dissociation and overall transport behavior in ...
Oscar Nordness, Leo W Gordon, Zidan Zhang, Venkat Ganesan, Raphaële J Clément   +4 more
doaj   +1 more source