Results 71 to 80 of about 387,863 (267)

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Numerical Study of Salt Ion Transport in Electromembrane Systems with Ion-Exchange Membranes Having Geometrically Structured Surfaces

Mathematics
This article is devoted to numerically modeling the effect of the geometric modification of the surfaces of ion-exchange membranes in electromembrane systems (EMSs) on the salt ion transport using a 2D mathematical model of the transport process in the ...
Evgenia Kirillova, Natalia Chubyr, Anna Kovalenko, Mahamet Urtenov   +3 more
doaj   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Assessment of the Risks Associated with the Handling and Transportation of Air Shipments Containing Lithium-Ion Batteries

Energies
Air transport, in addition to passenger transport, also transports air shipments containing hazardous materials. Hazardous materials include lithium-ion batteries, which can be carried both by passengers and by cargo aircraft.
Anna Kwasiborska, Sylwia Ścigaj
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Disentangling cation effects on ion mobility and structure in ionic liquid electrolytes

JPhys Energy
Ionic liquids (ILs) are low-temperature molten salts, where ion transport is primarily governed by ion–ion interactions. Yet, the impact of organic IL cations on critical electrolyte properties such as ion dissociation and overall transport behavior in ...
Oscar Nordness, Leo W Gordon, Zidan Zhang, Venkat Ganesan, Raphaële J Clément   +4 more
doaj   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Low-excitation transport and separation of high-mass-ratio mixed-species ion chains

Physical Review Research
We demonstrate low-excitation transport and separation of two-ion crystals consisting of one ^{9}Be^{+} and one ^{40}Ca^{+} ion, with a high mass ratio of 4.4.
F. Lancellotti, S. Welte, M. Simoni, C. Mordini, T. Behrle, B. de Neeve, M. Marinelli, V. Negnevitsky, J. P. Home   +8 more
doaj   +1 more source

Ion channels and transporters in metastasis

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2015
An elaborate interplay between ion channels and transporters, components of the cytoskeleton, adhesion molecules, and signaling cascades provides the basis for each major step of the metastatic cascade. Ion channels and transporters contribute to cell motility by letting through or transporting ions essential for local Ca2+, pH and--in cooperation with
Stock, Christian, Schwab, Albrecht
openaire   +2 more sources