Results 81 to 90 of about 390,019 (267)

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source

Naphthalene Diimide‐Based Metallacage as an Artificial Ion Channel for Chloride Ion Transport

Advanced Science
Developing synthetic molecular devices for controlling ion transmembrane transport is a promising research field in supramolecular chemistry. These artificial ion channels provide models to study ion channel diseases and have huge potential for ...
Qing‐Hui Ling, Yuanyuan Fu, Zhen‐Chen Lou, Bangkun Yue, Chenxing Guo, Xinyu Hu, Weiqiang Lu, Lianrui Hu, Wei Wang, Min Zhang, Hai‐Bo Yang, Lin Xu   +11 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

A physical derivation of high-flux ion transport in biological channel via quantum ion coherence

Nature Communications
Biological ion channels usually conduct the high-flux transport of 107 ~ 108 ions·s− 1; however, the underlying mechanism is still lacking. Here, by applying the KcsA potassium channel as a typical example, and performing multitimescale molecular ...
Yue Wang, Yixiao Hu, Jian-Ping Guo, Jun Gao, Bo Song, Lei Jiang   +5 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Compatibility of pronounced detachment with improved confinement on HL-2A tokamak

Nuclear Fusion
This paper investigates the compatibility of pronounced detachment with improved confinement based on the NBI-heated HL-2A L-mode plasma with low-density.
Ting Wu, Min Xu, Zhuo Wang, Lin Nie, Zhanhui Wang, Jinming Gao, Yihang Chen, Yiren Zhu, Yi Zhang, Liang Liu, Dong Li, Kai Zhang, Rui Ke, Xiaoxue He, Zengceng Yang, Xin Yu, Na Wu, Zhihui Huang, Kaiyang Yi, Weice Wang, Longwen Yan, Yonggao Li, Ting Long, Renxu Wang, Wenjing Tian, Zhe Wang, Laizhong Cai, Yi Yu   +27 more
doaj   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Speeding up adiabatic ion transport in macroscopic multi-Penning-trap stacks for high-precision experiments

Communications Physics
Multi-Penning traps are an excellent tool for high-precision tests of fundamental physics in a variety of applications, ranging from atomic mass measurements to symmetry tests.
Moritz von Boehn, Jan Schaper, Julia A. Coenders, Johannes Brombacher, Teresa Meiners, Malte Niemann, Juan M. Cornejo, Stefan Ulmer, Christian Ospelkaus   +8 more
doaj   +1 more source

Determining Partitioning Rate Constants and Diffusion Coefficients in Ion-exchange Membranes Using Time-dependent Partitioning Measurements

Electrochemistry
This study investigates ion partitioning and transport mechanisms within ion-exchange membranes (IEMs) and their influence on electrodialysis (ED) permselectivity.
Yu SUGIMOTO
doaj   +1 more source