Results 101 to 110 of about 3,526,732 (300)

Photodriven Active Ion Transport Through a Janus Microporous Membrane

, 2020
Precise control of ion transport is a fundamental characteristic for the sustainability of life. It remains a great challenge to develop practical and high‐performance artificial ion‐transport system that can allow active transport of ions (protons) in ...
Tang, Zhiyong, Huang, Zhiwei, Xiao He, Yu, Lian, Yaping Feng, Yang, Jinlei, Feng, Yaping, Zhiyong Tang, Jinlei Yang, Lianshan Li, Junjun Hou, Zhiwei Huang, Li, Lianshan, Liu, Pengchao, Hou, Junjun, Pengchao Liu, He, Xiao, Lian Yu   +17 more
core   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Ion channels and transporters in osteoclasts

Archives of Biochemistry and Biophysics, 2008
The resorbing osteoclast is an exceptional cell that secretes large amounts of acid through the coupled activity of a v-type H+-ATPase and a chloride channel that both reside in the ruffled membrane. Impairment of this acid secretion machinery by genetic mutations can abolish bone resorption activity, resulting in osteopetrotic phenotypes.
Supanchart, Chayarop, Kornak, Uwe
openaire   +3 more sources

Coupled Transport in Li-ion Battery Electrolytes [PDF]

Electrolytes are materials that contain mobile charge carriers – ions. The electrolyte in lithium-ion batteries enables the transport of positive Li+ ions in between the electrodes during battery operation.
Gullbrekken, Øystein
core   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Naphthalene Diimide‐Based Metallacage as an Artificial Ion Channel for Chloride Ion Transport

Advanced Science
Developing synthetic molecular devices for controlling ion transmembrane transport is a promising research field in supramolecular chemistry. These artificial ion channels provide models to study ion channel diseases and have huge potential for ...
Qing‐Hui Ling, Yuanyuan Fu, Zhen‐Chen Lou, Bangkun Yue, Chenxing Guo, Xinyu Hu, Weiqiang Lu, Lianrui Hu, Wei Wang, Min Zhang, Hai‐Bo Yang, Lin Xu   +11 more
doaj   +1 more source

An ion channel in the company of a transporter

Journal of General Physiology, 2020
In the current issue of JGP, Lamothe and Kurata explore the functional relationship between the Kv1.2 potassium channel, with Kvβ1.2 bound to the interior aspect of the channel, and Slc7a5, a component of the neutral amino acid transporter LAT1.
openaire   +2 more sources

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

A physical derivation of high-flux ion transport in biological channel via quantum ion coherence

Nature Communications
Biological ion channels usually conduct the high-flux transport of 107 ~ 108 ions·s− 1; however, the underlying mechanism is still lacking. Here, by applying the KcsA potassium channel as a typical example, and performing multitimescale molecular ...
Yue Wang, Yixiao Hu, Jian-Ping Guo, Jun Gao, Bo Song, Lei Jiang   +5 more
doaj   +1 more source